KLF8 explained

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.^[1] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.^[2]

Interactions

KLF8 has been shown to interact with CTBP2.^[3]

Further reading

• van Vliet J, Turner J, Crossley M . Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription . Nucleic Acids Research . 28 . 9 . 1955–62 . May 2000 . 10756197 . 103308 . 10.1093/nar/28.9.1955 .
• Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L . Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation . Journal of Medical Genetics . 39 . 2 . 113–7 . Feb 2002 . 11836360 . 1735036 . 10.1136/jmg.39.2.113 .
• Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M . The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2 . The Journal of Biological Chemistry . 278 . 15 . 12786–95 . Apr 2003 . 12556451 . 10.1074/jbc.M300587200 . free .
• Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL . Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression . Molecular Cell . 11 . 6 . 1503–15 . Jun 2003 . 12820964 . 10.1016/S1097-2765(03)00179-5 . free .
• Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA . A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element . Blood Cells, Molecules & Diseases . 35 . 2 . 227–35 . 2006 . 16023392 . 10.1016/j.bcmd.2005.04.009 .
• Wang X, Zhao J . KLF8 transcription factor participates in oncogenic transformation . Oncogene . 26 . 3 . 456–61 . Jan 2007 . 16832343 . 10.1038/sj.onc.1209796 . free .
• Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ . George Stamatoyannopoulos . Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation . Journal of Molecular Biology . 366 . 4 . 1064–73 . Mar 2007 . 17224162 . 1907364 . 10.1016/j.jmb.2006.12.047 .
• Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J . Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion . Cancer Research . 67 . 15 . 7184–93 . Aug 2007 . 17671186 . 10.1158/0008-5472.CAN-06-4729 . free .

Notes and References

1. Web site: Entrez Gene: KLF8 Kruppel-like factor 8.
2. Web site: Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing. asm.org. 12 January 2019. Alister P. W. Funnell. etal. 15 December 2018. https://web.archive.org/web/20181215023604/https://mcb.asm.org/content/33/15/2976#sec-22. dead.
3. van Vliet J, Turner J, Crossley M . Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription . Nucleic Acids Research . 28 . 9 . 1955–62 . May 2000 . 10756197 . 103308 . 10.1093/nar/28.9.1955 .