KLF14 explained

Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.[1] The corresponding Klf14 mouse gene is known as Sp6.[2]

Function

KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ).[3] KLF14 is expressed in many tissues,[4] lacks introns, and is subject to parent-specific expression.[5]

KLF14 appears to be a master regulator of gene expression in adipose tissue.[6]

Protein structure

Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.

Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;[7] in the mouse its length is 325.

Clinical significance

There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.[8] [9]

External links

Notes and References

  1. Web site: Klf14 Kruppel-like factor 14 [Mus musculus] - Gene result |url=https://www.ncbi.nlm.nih.gov/gene/619665.
  2. Web site: Sp6 trans-acting transcription factor 6 [Mus musculus] - Gene result |url=https://www.ncbi.nlm.nih.gov/gene/83395.
  3. Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R . Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling . The Journal of Biological Chemistry . 284 . 10 . 6291–300 . Mar 2009 . 19088080 . 2649086 . 10.1074/jbc.M807791200 . free .
  4. Swamynathan SK . Krüppel-like factors: three fingers in control . Human Genomics . 4 . 4 . 263–70 . Apr 2010 . 20511139 . 2975451 . 10.1186/1479-7364-4-4-263 . free .
  5. Parker-Katiraee L, Carson AR, Yamada T, Arnaud P, Feil R, Abu-Amero SN, Moore GE, Kaneda M, Perry GH, Stone AC, Lee C, Meguro-Horike M, Sasaki H, Kobayashi K, Nakabayashi K, Scherer SW . Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution . PLOS Genetics . 3 . 5 . e65 . May 2007 . 17480121 . 1865561 . 10.1371/journal.pgen.0030065 . free .
  6. Small KS, Hedman AK, Grundberg E, Nica AC, Thorleifsson G, Kong A, Thorsteindottir U, Shin SY, Richards HB, Soranzo N, Ahmadi KR, Lindgren CM, Stefansson K, Dermitzakis ET, Deloukas P, Spector TD, McCarthy MI . Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes . Nature Genetics . 43 . 6 . 561–4 . Jun 2011 . 21572415 . 3192952 . 10.1038/ng.833 .
  7. Web site: Krüppel-like factor 14 . Human Protein Reference Database . Johns Hopkins University . 2011-05-18 .
  8. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI . 6 . Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis . Nature Genetics . 42 . 7 . 579–89 . Jul 2010 . 20581827 . 3080658 . 10.1038/ng.609 .
  9. Grarup N, Sparsø T, Hansen T . Physiologic characterization of type 2 diabetes-related loci . Current Diabetes Reports . 10 . 6 . 485–97 . Dec 2010 . 20886378 . 2955912 . 10.1007/s11892-010-0154-y .

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