KLF12 explained

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.^{[1] [2]}

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.^[3]

See also

• Kruppel-like factors

Further reading

• Imhof A, Schuierer M, Werner O, etal . Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor . Mol. Cell. Biol. . 19 . 1 . 194–204 . 1999 . 9858544 . 10.1128/MCB.19.1.194. 83878 .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Schuierer M, Hilger-Eversheim K, Dobner T, etal . Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1 . J. Biol. Chem. . 276 . 30 . 27944–9 . 2001 . 11373277 . 10.1074/jbc.M100070200 . free .
• Zhu CH, Huang Y, Broman MT, Domann FE . Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter . Biochim. Biophys. Acta . 1519 . 1–2 . 85–91 . 2001 . 11406275 . 10.1016/s0167-4781(01)00227-5.
• Chen C, Brabham WW, Stultz BG, etal . Defining a common region of deletion at 13q21 in human cancers . Genes Chromosomes Cancer . 31 . 4 . 333–44 . 2001 . 11433524 . 10.1002/gcc.1152 . 42200056 .
• Rozenblum E, Vahteristo P, Sandberg T, etal . A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes . Hum. Genet. . 110 . 2 . 111–21 . 2002 . 11935316 . 10.1007/s00439-001-0646-6 . 21371347 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Dunham A, Matthews LH, Burton J, etal . The DNA sequence and analysis of human chromosome 13 . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Suda S, Rai T, Sohara E, etal . Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter . Biochem. Biophys. Res. Commun. . 344 . 1 . 246–52 . 2006 . 16615998 . 10.1016/j.bbrc.2006.03.138 .

Notes and References

1. Roth C, Schuierer M, Gunther K, Buettner R . Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12) . Genomics . 63 . 3 . 384–90 . Jul 2000 . 10704285 . 10.1006/geno.1999.6084 .
2. Web site: Entrez Gene: KLF12 Kruppel-like factor 12.
3. Web site: Entrez Gene: KLF12 Kruppel-like factor 12.