KLF10 explained

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.^{[1] [2] [3]}

See also

• Kruppel-like factors

Further reading

• Subramaniam M, Harris SA, Oursler MJ, etal . Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. . Nucleic Acids Res. . 23 . 23 . 4907–12 . 1996 . 8532536 . 10.1093/nar/23.23.4907 . 307482 .
• Tachibana I, Imoto M, Adjei PN, etal . Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. . J. Clin. Invest. . 99 . 10 . 2365–74 . 1997 . 9153278 . 10.1172/JCI119418 . 508075 .
• Subramaniam M, Hefferan TE, Tau K, etal . Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene. . J. Cell. Biochem. . 68 . 2 . 226–36 . 1998 . 9443078 . 10.1002/(SICI)1097-4644(19980201)68:2<226::AID-JCB9>3.0.CO;2-X . 35735351 .
• Cook T, Gebelein B, Mesa K, etal . Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. . J. Biol. Chem. . 273 . 40 . 25929–36 . 1998 . 9748269 . 10.1074/jbc.273.40.25929 . free .
• Hefferan TE, Reinholz GG, Rickard DJ, etal . Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. . J. Biol. Chem. . 275 . 27 . 20255–9 . 2000 . 10816551 . 10.1074/jbc.C000135200 . free .
• Gunther M, Laithier M, Brison O . A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. . Mol. Cell. Biochem. . 210 . 1–2 . 131–42 . 2000 . 10976766 . 10.1023/A:1007177623283 . 1339642 .
• Antonello D, Moore PS, Zamboni G, etal . Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer. . Cancer Lett. . 183 . 2 . 179–83 . 2002 . 12065093 . 10.1016/S0304-3835(01)00802-3 .
• Johnsen SA, Subramaniam M, Monroe DG, etal . Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. . J. Biol. Chem. . 277 . 34 . 30754–9 . 2002 . 12072443 . 10.1074/jbc.M204812200 . free.
• Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC . TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. . Oncogene . 21 . 37 . 5783–90 . 2002 . 12173049 . 10.1038/sj.onc.1205681 . 6218804 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chrisman HR, Tindall DJ . Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha. . DNA Cell Biol. . 22 . 3 . 187–99 . 2003 . 12804117 . 10.1089/104454903321655819 .
• Noti JD, Johnson AK, Dillon JD . The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter. . J. Biol. Chem. . 279 . 26 . 26948–58 . 2004 . 15087465 . 10.1074/jbc.M310634200 . free .
• Reinholz MM, An MW, Johnsen SA, etal . Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue. . Breast Cancer Res. Treat. . 86 . 1 . 75–88 . 2004 . 15218362 . 10.1023/B:BREA.0000032926.74216.7d . 25869980 .
• Johnsen SA, Subramaniam M, Effenberger KE, Spelsberg TC . The TGFβ Inducible Early Gene Plays a Central Role in the Anti-Proliferative Response to TGFβ. . Signal Transduction . 4 . 29–35 . 2004 . 1–2 . 10.1002/sita.200400032 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC . TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro. . Mol. Cell. Biol. . 25 . 1191–1199 . 2005 . 15657444 . 10.1128/MCB.25.3.1191-1199.2005 . 3 . 543998 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Fueki N, Sagara H, Akimoto K, etal . Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells. . Respiration; International Review of Thoracic Diseases . 74 . 4 . 454–9 . 2007 . 17377371 . 10.1159/000101057 . 20399180 .
• Jin W, Di G, Li J, etal . TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade. . FEBS Lett. . 581 . 20 . 3826–32 . 2007 . 17659279 . 10.1016/j.febslet.2007.07.008 . 20445009 . free .
• Subramaniam M, Hawse JR, Johnsen SA, Spelsberg TC . TIEG1: An Important Regulator of Multiple Biological Processes and Disease States. . J. Cell. Biochem. . 102 . 3 . 539–548 . 2007 . 17729309 . 10.1002/jcb.21492 . 42592049 .

Notes and References

1. Blok LJ, Grossmann ME, Perry JE, Tindall DJ . Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation . Mol Endocrinol . 9 . 11 . 1610–20 . Mar 1996 . 10.1210/mend.9.11.8584037 . 8584037 . 22515863 . free .
2. Fautsch MP, Vrabel A, Subramaniam M, Hefferen TE, Spelsberg TC, Wieben ED . TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters . Genomics . 51 . 3 . 408–16 . Oct 1998 . 9721211 . 10.1006/geno.1998.5388 .
3. Web site: Entrez Gene: KLF10 Kruppel-like factor 10.