KLC3 explained

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.^[1]

Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.

Interactions

KLC3 has been shown to interact with YWHAH.^[2]

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Zhang Y, Oko R, van der Hoorn FA . Rat kinesin light chain 3 associates with spermatid mitochondria . Developmental Biology . 275 . 1 . 23–33 . Nov 2004 . 15464570 . 3138780 . 10.1016/j.ydbio.2004.07.014 .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . Aug 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn FA . Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion . The Journal of Biological Chemistry . 278 . 18 . 16159–68 . May 2003 . 12594206 . 3178653 . 10.1074/jbc.M213126200 . free .
• Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T . Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet . The Journal of Cell Biology . 159 . 3 . 431–40 . Nov 2002 . 12427867 . 2173070 . 10.1083/jcb.200207153 .
• Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T . Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein . Biochemistry . 41 . 17 . 5566–72 . Apr 2002 . 11969417 . 10.1021/bi015946f .
• Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA . Kinesin light-chain KLC3 expression in testis is restricted to spermatids . Biology of Reproduction . 64 . 5 . 1320–30 . May 2001 . 11319135 . 3161965 . 10.1095/biolreprod64.5.1320 .
• Rahman A, Kamal A, Roberts EA, Goldstein LS . Defective kinesin heavy chain behavior in mouse kinesin light chain mutants . The Journal of Cell Biology . 146 . 6 . 1277–88 . Sep 1999 . 10491391 . 2156125 . 10.1083/jcb.146.6.1277 .
• Rahman A, Friedman DS, Goldstein LS . Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins . The Journal of Biological Chemistry . 273 . 25 . 15395–403 . Jun 1998 . 9624122 . 10.1074/jbc.273.25.15395 . free .
• Lamerdin JE, Stilwagen SA, Ramirez MH, Stubbs L, Carrano AV . Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes . Genomics . 34 . 3 . 399–409 . Jun 1996 . 8786141 . 10.1006/geno.1996.0303 .

Notes and References

1. Web site: Entrez Gene: KLC3 kinesin light chain 3.
2. Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T . Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein . Biochemistry . 41 . 17 . 5566–72 . Apr 2002 . 11969417 . 10.1021/bi015946f .