KIRREL2 explained

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.^{[1] [2] [3]} It is primarily expressed in β cells of the pancreatic islets.

KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3).

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rinta-Valkama J, Aaltonen P, Lassila M, etal . Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes. . Diabetes Metab. Res. Rev. . 23 . 2 . 119–26 . 2007 . 16741999 . 10.1002/dmrr.655 . 30494486 .

Notes and References

1. Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP . Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets . Genomics . 82 . 2 . 130–42 . Jul 2003 . 12837264 . 10.1016/S0888-7543(03)00110-1 .
2. Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H . Filtrin is a novel member of nephrin-like proteins . Biochem Biophys Res Commun . 300 . 2 . 364–70 . Dec 2002 . 12504092 . 10.1016/S0006-291X(02)02854-1 .
3. Web site: Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila).