KIN (gene) explained
DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene.[1] [2]
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.[2]
Further reading
- Biard DS, Saintigny Y, Maratrat M, etal . Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin. . Arch. Dermatol. Res. . 289 . 8 . 448–56 . 1997 . 9266022 . 10.1007/s004030050220 . 25828778 .
- Kannouche P, Angulo JF . Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells. . J. Cell Sci. . 112 . 19. 3215–24 . 1999 . 10.1242/jcs.112.19.3215 . 10504327 .
- Blattner C, Kannouche P, Litfin M, etal . UV-Induced stabilization of c-fos and other short-lived mRNAs. . Mol. Cell. Biol. . 20 . 10 . 3616–25 . 2000 . 10779351 . 10.1128/MCB.20.10.3616-3625.2000 . 85654 .
- Kannouche P, Mauffrey P, Pinon-Lataillade G, etal . Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. . Carcinogenesis . 21 . 9 . 1701–10 . 2000 . 10964102 . 10.1093/carcin/21.9.1701 . free .
- Biard DS, Miccoli L, Despras E, etal . Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. . J. Biol. Chem. . 277 . 21 . 19156–65 . 2002 . 11880372 . 10.1074/jbc.M200321200 . free .
- Miccoli L, Biard DS, Créminon C, Angulo JF . Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. . Cancer Res. . 62 . 19 . 5425–35 . 2002 . 12359749 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Masson C, Menaa F, Pinon-Lataillade G, etal . Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 2 . 616–21 . 2003 . 12525703 . 10.1073/pnas.0236176100 . 141045 . 2003PNAS..100..616M . free .
- Despras E, Miccoli L, Créminon C, etal . Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells. . Radiat. Res. . 159 . 6 . 748–58 . 2003 . 12751957 . 10.1667/0033-7587(2003)159[0748:DOKAHD]2.0.CO;2 . 2003RadR..159..748D . 10841640 . 0033-7587 .
- Biard DS, Miccoli L, Despras E, etal . Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes . Mol. Cancer Res. . 1 . 7 . 519–31 . 2004 . 12754299 .
- Miccoli L, Biard DS, Frouin I, etal . Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner . Nucleic Acids Res. . 31 . 14 . 4162–75 . 2003 . 12853634 . 10.1093/nar/gkg459 . 165974 .
- Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
- Miccoli L, Frouin I, Novac O, etal . The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins . Mol. Cell. Biol. . 25 . 9 . 3814–30 . 2005 . 15831485 . 10.1128/MCB.25.9.3814-3830.2005 . 1084281 .
- le Maire A, Schiltz M, Braud S, etal . Crystallization and halide phasing of the C-terminal domain of human KIN17 . Acta Crystallographica Section F . 62 . Pt 3 . 245–8 . 2006 . 16511313 . 10.1107/S174430910600409X . 2197188 .
- le Maire A, Schiltz M, Stura EA, etal . A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics . J. Mol. Biol. . 364 . 4 . 764–76 . 2007 . 17045609 . 10.1016/j.jmb.2006.09.033 .
Notes and References
- Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R . Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein . Nucleic Acids Res . 19 . 19 . 5117–23 . Nov 1991 . 1923796 . 328864 . 10.1093/nar/19.19.5117 .
- Web site: Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse).