KIFC1 explained

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

Function

The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.

Further reading

• Miki H, Setou M, Kaneshiro K, Hirokawa N . All kinesin superfamily protein, KIF, genes in mouse and human . Proc. Natl. Acad. Sci. U.S.A. . 98 . 13 . 7004–7011 . 2001 . 11416179 . 34614 . 10.1073/pnas.111145398 . 2001PNAS...98.7004M . free .
• Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A . Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS) . Immunogenetics . 49 . 7–8 . 644–652 . 1999 . 10369922 . 10.1007/s002510050660 . 25729892 .
• Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA . Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis . J. Cell Biol. . 162 . 5 . 863–875 . 2003 . 12939256 . 2172827 . 10.1083/jcb.200306009 .
• Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA . Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 . J. Cell Biol. . 166 . 2 . 167–172 . 2004 . 15263015 . 2172317 . 10.1083/jcb.200403084 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Al-Bassam J, Roger B, Halpain S, Milligan RA . Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c . Cell Motil. Cytoskeleton . 64 . 5 . 377–389 . 2007 . 17326138 . 10.1002/cm.20190 .