KIF5B explained

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene.^{[1] [2]} It is part of the kinesin family of motor proteins.

Interactions

KIF5B has been shown to interact with:

• KLC1,
• KLC2,^{[3] [4]}
• SNAP-25,^[5]
• SNAP23,^[5] and
• YWHAH.^[6]

Further reading

• Niclas J, Navone F, Hom-Booher N, Vale RD . Cloning and localization of a conventional kinesin motor expressed exclusively in neurons . Neuron . 12 . 5 . 1059–72 . May 1994 . 7514426 . 10.1016/0896-6273(94)90314-X . 32927183 .
• Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD . Crystal structure of the kinesin motor domain reveals a structural similarity to myosin . Nature . 380 . 6574 . 550–5 . Apr 1996 . 8606779 . 2851642 . 10.1038/380550a0 . 1996Natur.380..550J .
• Rahman A, Friedman DS, Goldstein LS . Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins . The Journal of Biological Chemistry . 273 . 25 . 15395–403 . Jun 1998 . 9624122 . 10.1074/jbc.273.25.15395 . free .
• Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, Hirokawa N . Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria . Cell . 93 . 7 . 1147–58 . Jun 1998 . 9657148 . 10.1016/S0092-8674(00)81459-2 . 17524297 . free .
• Rahman A, Kamal A, Roberts EA, Goldstein LS . Defective kinesin heavy chain behavior in mouse kinesin light chain mutants . The Journal of Cell Biology . 146 . 6 . 1277–88 . Sep 1999 . 10491391 . 2156125 . 10.1083/jcb.146.6.1277 .
• Ong LL, Lim AP, Er CP, Kuznetsov SA, Yu H . Kinectin-kinesin binding domains and their effects on organelle motility . The Journal of Biological Chemistry . 275 . 42 . 32854–60 . Oct 2000 . 10913441 . 10.1074/jbc.M005650200 . free .
• Kanai Y, Okada Y, Tanaka Y, Harada A, Terada S, Hirokawa N . KIF5C, a novel neuronal kinesin enriched in motor neurons . The Journal of Neuroscience . 20 . 17 . 6374–84 . Sep 2000 . 10964943 . 6772948 . 10.1523/JNEUROSCI.20-17-06374.2000.
• Setou M, Seog DH, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, Hirokawa N . Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites . Nature . 417 . 6884 . 83–7 . May 2002 . 11986669 . 10.1038/nature743 . 2002Natur.417...83S . 4400494 .
• Hakimi MA, Speicher DW, Shiekhattar R . The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis . The Journal of Biological Chemistry . 277 . 40 . 36909–12 . Oct 2002 . 12191989 . 10.1074/jbc.C200434200 . free .
• Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL . The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 . Biochemistry . 41 . 50 . 14906–15 . Dec 2002 . 12475239 . 10.1021/bi026417u .
• Macioce P, Gambara G, Bernassola M, Gaddini L, Torreri P, Macchia G, Ramoni C, Ceccarini M, Petrucci TC . Beta-dystrobrevin interacts directly with kinesin heavy chain in brain . Journal of Cell Science . 116 . Pt 23 . 4847–56 . Dec 2003 . 14600269 . 10.1242/jcs.00805 . free .
• Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL . The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B . Biochemical and Biophysical Research Communications . 319 . 3 . 987–92 . Jul 2004 . 15184079 . 10.1016/j.bbrc.2004.05.069 .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . Aug 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Su Q, Cai Q, Gerwin C, Smith CL, Sheng ZH . Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons . Nature Cell Biology . 6 . 10 . 941–53 . Oct 2004 . 15459722 . 10.1038/ncb1169 . 6875457 .
• Brickley K, Smith MJ, Beck M, Stephenson FA . GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin . The Journal of Biological Chemistry . 280 . 15 . 14723–32 . Apr 2005 . 15644324 . 10.1074/jbc.M409095200 . free .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Molecular & Cellular Proteomics . 4 . 6 . 785–95 . Jun 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .

Notes and References

1. Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD . Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells . The Journal of Cell Biology . 117 . 6 . 1263–75 . Jun 1992 . 1607388 . 2289507 . 10.1083/jcb.117.6.1263 .
2. Web site: Entrez Gene: KIF5B kinesin family member 5B.
3. Rahman A, Friedman DS, Goldstein LS . Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins . The Journal of Biological Chemistry . 273 . 25 . 15395–403 . Jun 1998 . 9624122 . 10.1074/jbc.273.25.15395. free .
4. Rahman A, Kamal A, Roberts EA, Goldstein LS . Defective kinesin heavy chain behavior in mouse kinesin light chain mutants . The Journal of Cell Biology . 146 . 6 . 1277–88 . Sep 1999 . 10491391 . 2156125 . 10.1083/jcb.146.6.1277.
5. Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL . The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 . Biochemistry . 41 . 50 . 14906–15 . Dec 2002 . 12475239 . 10.1021/bi026417u.
6. Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T . Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein . Biochemistry . 41 . 17 . 5566–72 . Apr 2002 . 11969417 . 10.1021/bi015946f.