KIF4A explained

Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.^{[1] [2]}

Function

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.^[2]

Interactions

KIF4A has been shown to interact with HMG20B^[3] and DNMT3B.^[4]

Clinical significance

NTCP is the entry receptor for both Hepatitis B (HBV) and Hepatitis D viruses (HDV).^[5] KIF4 was found to play an essential role in HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV/HDV infection.^[6]

Further reading

• Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N . A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally . The Journal of Cell Biology . 127 . 1 . 187–201 . October 1994 . 7929562 . 2120182 . 10.1083/jcb.127.1.187 .
• Yan RT, Wang SZ . Increased chromokinesin immunoreactivity in retinoblastoma cells . Gene . 189 . 2 . 263–267 . April 1997 . 9168136 . 10.1016/S0378-1119(96)00860-8 .
• Tang Y, Winkler U, Freed EO, Torrey TA, Kim W, Li H, Goff SP, Morse HC . 6 . Cellular motor protein KIF-4 associates with retroviral Gag . Journal of Virology . 73 . 12 . 10508–10513 . December 1999 . 10559369 . 113106 . 10.1128/JVI.73.12.10508-10513.1999 .
• Oh S, Hahn H, Torrey TA, Shin H, Choi W, Lee YM, Morse HC, Kim W . 6 . Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1493 . 1–2 . 219–224 . September 2000 . 10978527 . 10.1016/s0167-4781(00)00151-2 .
• Lee YM, Lee S, Lee E, Shin H, Hahn H, Choi W, Kim W . Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis . The Biochemical Journal . 360 . Pt 3 . 549–556 . December 2001 . 11736643 . 1222256 . 10.1042/0264-6021:3600549 .
• Lee YM, Kim W . Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 . The Biochemical Journal . 374 . Pt 2 . 497–503 . September 2003 . 12809554 . 1223617 . 10.1042/BJ20030452 .
• Leonard D, Ajuh P, Lamond AI, Legerski RJ . hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing . Biochemical and Biophysical Research Communications . 308 . 4 . 793–801 . September 2003 . 12927788 . 10.1016/S0006-291X(03)01486-4 .
• Lee YM, Kim W . Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells . Experimental & Molecular Medicine . 36 . 1 . 93–97 . February 2004 . 15031677 . 10.1038/emm.2004.13 . free .
• Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD . 6 . Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery . Nucleic Acids Research . 32 . 9 . 2716–2729 . 2004 . 15148359 . 419596 . 10.1093/nar/gkh589 .
• Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K . Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation . The EMBO Journal . 23 . 16 . 3237–3248 . August 2004 . 15297875 . 514520 . 10.1038/sj.emboj.7600347 .
• Mazumdar M, Sundareshan S, Misteli T . Human chromokinesin KIF4A functions in chromosome condensation and segregation . The Journal of Cell Biology . 166 . 5 . 613–620 . August 2004 . 15326200 . 2172419 . 10.1083/jcb.200401142 .
• Zhu C, Jiang W . Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis . Proceedings of the National Academy of Sciences of the United States of America . 102 . 2 . 343–348 . January 2005 . 15625105 . 544298 . 10.1073/pnas.0408438102 . free . 2005PNAS..102..343Z .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . 6 . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–5396 . April 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . free . 2006PNAS..103.5391N .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–1292 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .

External links

• Web site: KIF4A Foundation .

Notes and References

1. Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W . Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization . Cytogenetics and Cell Genetics . 88 . 1–2 . 41–42 . Jun 2000 . 10773663 . 10.1159/000015482 . 46074226 .
2. Web site: Entrez Gene: KIF4A kinesin family member 4A.
3. Lee YM, Kim W . Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 . The Biochemical Journal . 374 . Pt 2 . 497–503 . September 2003 . 12809554 . 1223617 . 10.1042/BJ20030452 .
4. Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD . 6 . Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery . Nucleic Acids Research . 32 . 9 . 2716–2729 . 2004 . 15148359 . 419596 . 10.1093/nar/gkh589 .
5. 6 . Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J, Li W . November 2012 . Chen . Zhijian J . Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus . eLife . 1 . e00049 . 10.7554/eLife.00049 . 3485615 . 23150796 . free .
6. 6 . Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, Sureau C, Watanabe N, Kato T, Murayama A, Li Y, Shoji I, Shimotohno K, Chayama K, Muramatsu M, Wakita T, Nozaki T, Aly HH . March 2022 . The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro . PLOS Pathogens . 18 . 3 . e1009983 . 10.1371/journal.ppat.1009983 . 8970526 . 35312737 . free .