KIF2C explained

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.^{[1] [2]}

The protein encoded by this gene is a member of kinesin-like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2.^[3] Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.

Further reading

• Miki H, Setou M, Kaneshiro K, Hirokawa N . All kinesin superfamily protein, KIF, genes in mouse and human . Proceedings of the National Academy of Sciences of the United States of America . 98 . 13 . 7004–7011 . June 2001 . 11416179 . 34614 . 10.1073/pnas.111145398 . free . 2001PNAS...98.7004M .
• Maney T, Hunter AW, Wagenbach M, Wordeman L . Mitotic centromere-associated kinesin is important for anaphase chromosome segregation . The Journal of Cell Biology . 142 . 3 . 787–801 . August 1998 . 9700166 . 2148171 . 10.1083/jcb.142.3.787 .
• Wordeman L, Wagenbach M, Maney T . Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK) . Cell Biology International . 23 . 4 . 275–286 . 2000 . 10600236 . 10.1006/cbir.1999.0359 . 29403722 .
• Sugata N, Li S, Earnshaw WC, Yen TJ, Yoda K, Masumoto H, Munekata E, Warburton PE, Todokoro K . 6 . Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes . Human Molecular Genetics . 9 . 19 . 2919–2926 . November 2000 . 11092768 . 10.1093/hmg/9.19.2919 . free .
• Maney T, Wagenbach M, Wordeman L . Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin . The Journal of Biological Chemistry . 276 . 37 . 34753–34758 . September 2001 . 11466324 . 10.1074/jbc.M106626200 . free .
• Cheng LJ, Zhou ZM, Li JM, Zhu H, Zhu H, Zhou YD, Wang LR, Lin M, Sha JH . 6 . Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis . Life Sciences . 71 . 23 . 2741–2757 . October 2002 . 12383881 . 10.1016/S0024-3205(02)02079-9 .
• Cassimeris L, Morabito J . TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly . Molecular Biology of the Cell . 15 . 4 . 1580–1590 . April 2004 . 14718566 . 379257 . 10.1091/mbc.E03-07-0544 .
• Ganem NJ, Compton DA . The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK . The Journal of Cell Biology . 166 . 4 . 473–478 . August 2004 . 15302853 . 2172212 . 10.1083/jcb.200404012 .
• Newton CN, Wagenbach M, Ovechkina Y, Wordeman L, Wilson L . MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro . FEBS Letters . 572 . 1–3 . 80–84 . August 2004 . 15304328 . 10.1016/j.febslet.2004.06.093 . free .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . January 2005 . 15635413 . 10.1038/nature03207 . 4344740 . 2005Natur.433...77A .
• Moore AT, Rankin KE, von Dassow G, Peris L, Wagenbach M, Ovechkina Y, Andrieux A, Job D, Wordeman L . 6 . MCAK associates with the tips of polymerizing microtubules . The Journal of Cell Biology . 169 . 3 . 391–397 . May 2005 . 15883193 . 2171944 . 10.1083/jcb.200411089 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . 2005Natur.437.1173R .
• Ganem NJ, Upton K, Compton DA . Efficient mitosis in human cells lacking poleward microtubule flux . Current Biology . 15 . 20 . 1827–1832 . October 2005 . 16243029 . 10.1016/j.cub.2005.08.065 . 8541946 . free . 2005CBio...15.1827G .
• Helenius J, Brouhard G, Kalaidzidis Y, Diez S, Howard J . The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends . Nature . 441 . 7089 . 115–119 . May 2006 . 16672973 . 10.1038/nature04736 . 4408328 . 10.1.1.392.1014 . 2006Natur.441..115H .
• Sun Y, Huang YC, Xu QZ, Wang HP, Bai B, Sui JL, Zhou PK . HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation . International Journal of Radiation Oncology, Biology, Physics . 65 . 3 . 842–850 . July 2006 . 16751065 . 10.1016/j.ijrobp.2006.02.040 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Kim IG, Jun DY, Sohn U, Kim YH . Cloning and expression of human mitotic centromere-associated kinesin gene . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1359 . 3 . 181–186 . December 1997 . 9434124 . 10.1016/s0167-4889(97)00103-1 . free .
2. Web site: Entrez Gene: KIF2C kinesin family member 2C.
3. Wang W, Cantos-Fernandes S, Lv Y, Kuerban H, Ahmad S, Wang C, Gigant B . Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin . Nature Communications . 8 . 1 . 70 . July 2017 . 28694425 . 5503940 . 10.1038/s41467-017-00091-9 .