KIF22 explained

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.^[3]

Interactions

KIF22 has been shown to interact with SIAH1.^[4]

Clinical relevance

Mutations in this gene have been shown to cause developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.^[5]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Zhang S, Nonoyama M . The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family . Proc. Natl. Acad. Sci. U.S.A. . 91 . 7 . 2843–7 . 1994 . 8146198 . 10.1073/pnas.91.7.2843 . 43467 . 1994PNAS...91.2843Z . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Song J, Murakami H, Tsutsui H, etal . Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ) . J. Biol. Chem. . 273 . 32 . 20603–14 . 1998 . 9685418 . 10.1074/jbc.273.32.20603 . free .
• Song J, Murakami H, Yang ZQ, etal . Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2 . Genomics . 52 . 3 . 374–7 . 1998 . 9790757 . 10.1006/geno.1998.5452 .
• Loftus BJ, Kim UJ, Sneddon VP, etal . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q . Genomics . 60 . 3 . 295–308 . 1999 . 10493829 . 10.1006/geno.1999.5927 .
• Funabiki H, Murray AW . The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement . Cell . 102 . 4 . 411–24 . 2000 . 10966104 . 10.1016/S0092-8674(00)00047-7 . 3010084 . free .
• Antonio C, Ferby I, Wilhelm H, etal . Xkid, a chromokinesin required for chromosome alignment on the metaphase plate . Cell . 102 . 4 . 425–35 . 2000 . 10966105 . 10.1016/S0092-8674(00)00048-9 . 17113314 . free .
• Germani A, Bruzzoni-Giovanelli H, Fellous A, etal . SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis . Oncogene . 19 . 52 . 5997–6006 . 2001 . 11146551 . 10.1038/sj.onc.1204002 . free .
• Levesque AA, Compton DA . The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles . J. Cell Biol. . 154 . 6 . 1135–46 . 2001 . 11564754 . 10.1083/jcb.200106093 . 2150818 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yajima J, Edamatsu M, Watai-Nishii J, etal . The human chromokinesin Kid is a plus end-directed microtubule-based motor . EMBO J. . 22 . 5 . 1067–74 . 2003 . 12606572 . 10.1093/emboj/cdg102 . 150335 .
• Shiroguchi K, Ohsugi M, Edamatsu M, etal . The second microtubule-binding site of monomeric kid enhances the microtubule affinity . J. Biol. Chem. . 278 . 25 . 22460–5 . 2003 . 12692123 . 10.1074/jbc.M212274200 . free .
• Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, etal . Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes . EMBO J. . 22 . 9 . 2091–103 . 2003 . 12727876 . 10.1093/emboj/cdg208 . 156080 .
• Venkatesh LK, Gettemeier T, Chinnadurai G . A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein . J. Virol. . 77 . 13 . 7236–43 . 2003 . 12805422 . 10.1128/JVI.77.13.7236-7243.2003 . 164832 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T . The chromokinesin Kid is required for maintenance of proper metaphase spindle size . Mol. Biol. Cell . 16 . 11 . 5455–63 . 2006 . 16176979 . 10.1091/mbc.E05-03-0244 . 1266440 .

Notes and References

1. Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T . Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle . EMBO J . 15 . 3 . 457–67 . April 1996 . 8599929 . 449964 . 10.1002/j.1460-2075.1996.tb00378.x.
2. Miki H, Setou M, Kaneshiro K, Hirokawa N . All kinesin superfamily protein, KIF, genes in mouse and human . Proc Natl Acad Sci U S A . 98 . 13 . 7004–11 . June 2001 . 11416179 . 34614 . 10.1073/pnas.111145398 . 2001PNAS...98.7004M . free .
3. Web site: Entrez Gene: KIF22 kinesin family member 22.
4. Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F . SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis . Oncogene . 19 . 52 . 5997–6006 . 2000 . 11146551 . 10.1038/sj.onc.1204002 . free .
5. Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ . Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type . Am. J. Hum. Genet. . 89 . 6 . 760–6 . December 2011 . 22152677 . 10.1016/j.ajhg.2011.10.015 . 3234366.