KIF17 explained

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene.^[1] KIF17 and its close relative, C. elegans OSM-3, are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins. In contrast to heterotrimeric kinesin-2 motors, however, KIF17 and OSM-3 form distinct homodimeric complexes. Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane, whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.

Further reading

• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 1 . 65–73 . February 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
• Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P . CREM-dependent transcription in male germ cells controlled by a kinesin . Science . 298 . 5602 . 2388–90 . December 2002 . 12493914 . 10.1126/science.1077265 . 2002Sci...298.2388M . 42448155 .
• Guillaud L, Setou M, Hirokawa N . KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons . J. Neurosci. . 23 . 1 . 131–40 . January 2003 . 12514209 . 10.1523/JNEUROSCI.23-01-00131.2003. 6742138 . free .
• Chennathukuzhi V, Morales CR, El-Alfy M, Hecht NB . The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells . Proc. Natl. Acad. Sci. U.S.A. . 100 . 26 . 15566–71 . December 2003 . 14673085 . 307608 . 10.1073/pnas.2536695100 . 2003PNAS..10015566C . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY. Huda Zoghbi . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Web site: Entrez Gene: KIF17 kinesin family member 17.