KIAA1967 explained

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.^{[1] [2] [3]}

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53.^{[4] [5]} DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.^[6]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Nagase T, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins . DNA Res. . 8 . 6 . 319–27 . 2002 . 11853319 . 10.1093/dnares/8.6.319 .
• Hamaguchi M, Meth JL, von Klitzing C, etal . DBC2, a candidate for a tumor suppressor gene involved in breast cancer . Proc. Natl. Acad. Sci. U.S.A. . 99 . 21 . 13647–52 . 2002 . 12370419 . 10.1073/pnas.212516099 . 129730 . 2002PNAS...9913647H . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Ballif BA, Villén J, Beausoleil SA, etal . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Sundararajan R, Chen G, Mukherjee C, White E . Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling . Oncogene . 24 . 31 . 4908–20 . 2005 . 15824730 . 10.1038/sj.onc.1208681 . 28591041 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Koch HB, Zhang R, Verdoodt B, etal . Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach . Cell Cycle . 6 . 2 . 205–17 . 2007 . 17314511 . 10.4161/cc.6.2.3742 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Trauernicht AM, Kim SJ, Kim NH, Boyer TG . Modulation of estrogen receptor alpha protein level and survival function by DBC-1 . Mol. Endocrinol. . 21 . 7 . 1526–36 . 2007 . 17473282 . 10.1210/me.2007-0064 . free .

Notes and References

1. Web site: Entrez Gene: KIAA1967 KIAA1967.
2. Nagase T, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins . DNA Res. . 8 . 6 . 319–27 . December 2001 . 11853319 . 10.1093/dnares/8.6.319 .
3. Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH . DBC2, a candidate for a tumor suppressor gene involved in breast cancer . Proc. Natl. Acad. Sci. U.S.A. . 99 . 21 . 13647–52 . October 2002 . 12370419 . 129730 . 10.1073/pnas.212516099 . 2002PNAS...9913647H . free .
4. Kim JE, Chen J, Lou Z . DBC1 is a negative regulator of SIRT1 . Nature . 451 . 7178 . 583–6 . January 2008 . 18235501 . 10.1038/nature06500 . 2008Natur.451..583K . 4420753 .
5. Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W . Negative regulation of the deacetylase SIRT1 by DBC1 . Nature . 451 . 7178 . 587–90 . January 2008 . 18235502 . 10.1038/nature06515 . 2866287 . 2008Natur.451..587Z .
6. Anantharaman V, Aravind L . Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites . Cell Cycle . 7 . 10 . 1467–72 . May 2008 . 18418069 . 2423810 . 10.4161/cc.7.10.5883.