KIAA1279 explained

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene.^[1] The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator.^[2] Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis.^[3] Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis,^[4] and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

Clinical significance

Defects may be associated with Goldberg–Shprintzen syndrome (OMIM 609460).

Interactions

KIAA1279 has been shown to interact with Retinal G protein coupled receptor^[5] and Dipeptidase 1.^[5]

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Wozniak MJ, Melzer M, Dorner C, Haring HU, Lammers R . The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein . BMC Cell Biology . 6 . 35 . October 2005 . 16225668 . 1266353 . 10.1186/1471-2121-6-35 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Brooks AS, Bertoli-Avella AM, Burzynski GM, Breedveld GJ, Osinga J, Boven LG, Hurst JA, Mancini GM, Lequin MH, de Coo RF, Matera I, de Graaff E, Meijers C, Willems PJ, Tibboel D, Oostra BA, Hofstra RM . Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems . American Journal of Human Genetics . 77 . 1 . 120–6 . July 2005 . 15883926 . 1226183 . 10.1086/431244 .
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 6 . 5 . 337–45 . October 1999 . 10574462 . 10.1093/dnares/6.5.337 . free .

External links

• Online Mendelian Inheritance in Man entry on GOLDBERG-SHPRINTZEN MEGACOLON SYNDROME

Notes and References

1. Web site: Entrez Gene: KIAA1279 KIAA1279.
2. Brouwers N, Mallol Martinez N, Vernos I . Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment . PLOS ONE . 12 . 4 . e0174819 . 2017-04-26 . 28445502 . 5405935 . 10.1371/journal.pone.0174819 . 2017PLoSO..1274819B . free .
3. Vanneste D, Takagi M, Imamoto N, Vernos I . The role of Hklp2 in the stabilization and maintenance of spindle bipolarity . Current Biology . 19 . 20 . 1712–7 . November 2009 . 19818619 . 10.1016/j.cub.2009.09.019 . free . 2009CBio...19.1712V .
4. Sebastian J, Rathinasamy K . Benserazide Perturbs Kif15-kinesin Binding Protein Interaction with Prolonged Metaphase and Defects in Chromosomal Congression: A Study Based on in silico Modeling and Cell Culture . Molecular Informatics . minf.201900035 . July 2019 . 39 . 3 . 31347789 . 10.1002/minf.201900035 . 198911009 .
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . Huda Zoghbi . 2005Natur.437.1173R . 4427026 .