KDM4D explained
Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.[1] [2] KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.
In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material.[3] [4] A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.[5]
Further reading
- Shin S, Janknecht R . Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D . Biochemical and Biophysical Research Communications . 359 . 3 . 742–6 . August 2007 . 17555712 . 10.1016/j.bbrc.2007.05.179 .
- Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y . Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases . Cell . 125 . 3 . 467–81 . May 2006 . 16603238 . 10.1016/j.cell.2006.03.028 . 14461740 . free .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
Notes and References
- Katoh M, Katoh M . Identification and characterization of JMJD2 family genes in silico . International Journal of Oncology . 24 . 6 . 1623–8 . June 2004 . 15138608 . 10.3892/ijo.25.3.759 .
- Web site: Entrez Gene: JMJD2D jumonji domain containing 2D.
- Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q . Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer . Cell . 172 . 4 . 881–887.e7 . February 2018 . 29395327 . 10.1016/j.cell.2018.01.020 . free .
- Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep . Rob . Stein . vanc . National Public Radio . 24 January 2018 . 24 January 2018 .
- Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y . H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming . Development . 145 . 4 . February 2018 . dev158261 . 29453221 . 10.1242/dev.158261 . free .