KDM3A explained

Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene.^[1]

Function

This gene encodes a zinc finger protein that contains a jumonji C (JmjC) domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. KDM3A catalyzes the demethylation of H3K9me1 and H3K9me2 residues. Its function is dependent on the presence of cofactors Fe(II) and α-Ketoglutarate.^[2]

Further reading

• Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M, Eltzschig HK, Bührer C . Hypoxia upregulates the histone demethylase JMJD1A via HIF-1 . Biochemical and Biophysical Research Communications . 372 . 4 . 892–897 . August 2008 . 18538129 . 10.1016/j.bbrc.2008.05.150 .

Notes and References

1. Web site: Entrez Gene: Lysine demethylase 3A .
2. Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y . JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor . Cell . 125 . 3 . 483–495 . May 2006 . 16603237 . 10.1016/j.cell.2006.03.027 . 6643329 . free .