KDM1B explained
Lysine (K)-specific demethylase 1B is a protein that in humans is encoded by the KDM1B gene.[1]
Function
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function.[1] [2]
Further reading
- Yu H, Mashtalir N, Daou S, Hammond-Martel I, Ross J, Sui G, Hart GW, Rauscher FJ, Drobetsky E, Milot E, Shi Y, Affar el B . The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression . Molecular and Cellular Biology . 30 . 21 . 5071–85 . Nov 2010 . 20805357 . 2953049 . 10.1128/MCB.00396-10 .
- Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi Y, Shi YG . Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation . Molecular Cell . 39 . 2 . 222–33 . Jul 2010 . 20670891 . 3518444 . 10.1016/j.molcel.2010.07.008 .
- Ciccone DN, Su H, Hevi S, Gay F, Lei H, Bajko J, Xu G, Li E, Chen T . KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints . Nature . 461 . 7262 . 415–8 . Sep 2009 . 19727073 . 10.1038/nature08315 . 2009Natur.461..415C . 1143128 .
- Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A . The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1 . The Journal of Biological Chemistry . 284 . 49 . 34179–88 . Dec 2009 . 19815555 . 2797188 . 10.1074/jbc.M109.046755 . free .
Notes and References
- Web site: Entrez Gene: Lysine (K)-specific demethylase 1B .
- Karytinos A, Forneris F, Profumo A, Ciossani G, Battaglioli E, Binda C, Mattevi A . A novel mammalian flavin-dependent histone demethylase . The Journal of Biological Chemistry . 284 . 26 . 17775–82 . Jun 2009 . 19407342 . 2719416 . 10.1074/jbc.M109.003087 . free .
