KCTD13 explained

BTB/POZ domain-containing protein KCTD13 is a protein that in humans is encoded by the KCTD13 gene.^{[1] [2]}

Interactions

KCTD13 has been shown to interact with PCNA.

Clinical relevance

Mutations in this gene have been associated to abnormalities in brain growth and behaviour.^[3]

Further reading

• Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER . NotI flanking sequences: a tool for gene discovery and verification of the human genome . Nucleic Acids Research . 30 . 14 . 3163–70 . July 2002 . 12136098 . 135748 . 10.1093/nar/gkf428 .
• Zhou J, Hu X, Xiong X, Liu X, Liu Y, Ren K, Jiang T, Hu X, Zhang J . Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen . Journal of Experimental Zoology A . 303 . 3 . 227–40 . March 2005 . 15726626 . 10.1002/jez.a.150 . 2005JEZA..303..227Z .
• Tomaru T, Satoh T, Yoshino S, Ishizuka T, Hashimoto K, Monden T, Yamada M, Mori M . Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma . Endocrinology . 147 . 1 . 377–88 . January 2006 . 16239304 . 10.1210/en.2005-0450 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human KCTD13

Notes and References

1. He H, Tan CK, Downey KM, So AG . A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen . Proceedings of the National Academy of Sciences of the United States of America . 98 . 21 . 11979–84 . October 2001 . 11593007 . 59753 . 10.1073/pnas.221452098 . 2001PNAS...9811979H . free .
2. Web site: Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13.
3. Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, Aneichyk T, Lerch JP, Qiu LR, Rodriguiz RM, Henkelman RM, Talkowski ME, Wetsel WC, Golzio C, Katsanis N . Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions . Human Molecular Genetics . 28 . 9 . 1474–1486 . May 2019 . 30590535 . 6489413 . 10.1093/hmg/ddy436 .