KCNRG explained

Potassium channel regulator, also known as KCNRG, is a protein which in humans is encoded by theKCNRG gene.^{[1] [2]}

Function

KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K⁺ channels and inhibits their function.

Clinical significance

KCNRG has been found to be predominantly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent.Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis.^[3]

Further reading

• Cho YG . Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas . Exp. Mol. Med. . 38 . 3 . 247–55 . 2006 . 16819283 . 10.1038/emm.2006.30. vanc. Kim CJ . Song JH . 3 . Rhie . DJ . Park . YK . Kim . SY . Nam . SW . Yoo . NJ . Lee . JY . free .
• Skoblov M . Human RFP2 gene promoter: Unique structure and unusual strength . Biochem. Biophys. Res. Commun. . 342 . 3 . 859–66 . 2006 . 16499869 . 10.1016/j.bbrc.2006.01.187 . 1994241 . vanc. Shakhbazov K . Oshchepkov D . 3 . Ivanov . Dmitry . Guskova . Anna . Ivanov . Dmitry . Rubtsov . Petr . Prasolov . Vladimir . Yankovsky . Nick .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Corcoran MM . DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse . Genes Chromosomes Cancer . 40 . 4 . 285–97 . 2004 . 15188451 . 10.1002/gcc.20046 . vanc. Hammarsund M . Zhu C . 3 . Lerner . Mikael . Kapanadze . Bagrat . Wilson . Bill . Larsson . Catharina . Forsberg . Lars . Ibbotson . Rachel E. . 35917986 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Ivanov DV . A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3 . FEBS Lett. . 539 . 1–3 . 156–60 . 2003 . 12650944 . 10.1016/S0014-5793(03)00211-4 . vanc. Tyazhelova TV . Lemonnier L . 3 . Kononenko . N . Pestova . AA . Nikitin . EA . Prevarskaya . N . Skryma . R . Panchin . YV . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Web site: Entrez Gene: KCNRG potassium channel regulator.
2. Ivanov DV, Tyazhelova TV, Lemonnier L, Kononenko N, Pestova AA, Nikitin EA, Prevarskaya N, Skryma R, Panchin YV, Yankovsky NK, Baranova AV . A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3 . FEBS Lett. . 539 . 1–3 . 156–60 . March 2003 . 12650944 . 10.1016/S0014-5793(03)00211-4 . free .
3. Alimohammadi M, Dubois N, Sköldberg F, Hallgren A, Tardivel I, Hedstrand H, Haavik J, Husebye ES, Gustafsson J, Rorsman F, Meloni A, Janson C, Vialettes B, Kajosaari M, Egner W, Sargur R, Pontén F, Amoura Z, Grimfeld A, De Luca F, Betterle C, Perheentupa J, Kämpe O, Carel JC . Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen . Proc. Natl. Acad. Sci. U.S.A. . 106. 11. 4396–401. February 2009 . 19251657 . 2648890 . 10.1073/pnas.0809986106 . 2009PNAS..106.4396A . free .