KCNQ5 explained

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.^{[1] [2] [3] [4]}

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.^[5]

Interactions

KCNQ5 has been shown to interact with KvLQT3.^[6]

See also

• Voltage-gated potassium channel

Further reading

• Wickenden AD, Zou A, Wagoner PK, Jegla T . Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. . Br. J. Pharmacol. . 132 . 2 . 381–4 . 2001 . 11159685 . 10.1038/sj.bjp.0703861 . 1572592 .
• Yus-Najera E, Santana-Castro I, Villarroel A . The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. . J. Biol. Chem. . 277 . 32 . 28545–53 . 2002 . 12032157 . 10.1074/jbc.M204130200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ozeki Y, Tomoda T, Kleiderlein J, etal . Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 1 . 289–94 . 2003 . 12506198 . 10.1073/pnas.0136913100 . 140954 . 2003PNAS..100..289O . free .
• Yus-Nájera E, Muñoz A, Salvador N, etal . Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation. . Neuroscience . 120 . 2 . 353–64 . 2003 . 12890507 . 10.1016/S0306-4522(03)00321-X . 38381189 .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . free . 2003Natur.425..805M .
• Li Y, Langlais P, Gamper N, etal . Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. . J. Biol. Chem. . 279 . 44 . 45399–407 . 2004 . 15304482 . 10.1074/jbc.M408410200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Jensen HS, Grunnet M, Olesen SP . Inactivation as a new regulatory mechanism for neuronal Kv7 channels. . Biophys. J. . 92 . 8 . 2747–56 . 2007 . 17237198 . 10.1529/biophysj.106.101287 . 1831682 . 2007BpJ....92.2747J .

Notes and References

1. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K . Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity . J Biol Chem . 275 . 29 . 22395–400 . Aug 2000 . 10787416 . 10.1074/jbc.M002378200 . free .
2. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ . KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents . J Biol Chem . 275 . 31 . 24089–95 . Sep 2000 . 10816588 . 10.1074/jbc.M003245200 . free .
3. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X . International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels . Pharmacol Rev . 57 . 4 . 473–508 . Dec 2005 . 16382104 . 10.1124/pr.57.4.10 . 219195192 .
4. Web site: Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5.
5. Web site: Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5.
6. 10.1016/S0306-4522(03)00321-X . Yus-Nájera . E . Muñoz A . Salvador N . Jensen B S . Rasmussen H B . Defelipe J . Villarroel A . 2003. Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation . Neuroscience . 120 . 2 . 353–64 . 0306-4522. 12890507 . 38381189 .