KCNQ1DN explained
| KCNQ1 downstream neighbour |
| Symbol: | KCNQ1DN |
| Rfam: | RF01961 |
| Rna Type: | Gene |
| Tax Domain: | Eukaryota |
KCNQ1 downstream neighbour (KCNQ1DN) is a long non-coding RNA gene. In humans, it is located on chromosome 11p15.5 between the CDKN1C and KCNQ1 genes. It is an imprinted gene, expressed from the maternal allele. Reduced expression of KCNQ1DN is observed in Wilms' tumours.[1]
See also
Further reading
- Engemann S, Strodicke M, Paulsen M, etal . Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting. . Hum. Mol. Genet. . 9 . 18 . 2691–2706 . 2000 . 11063728 . 10.1093/hmg/9.18.2691. free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
Notes and References
- Xin Z, Soejima H, Higashimoto K, etal . A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors . J. Biochem. . 128 . 5 . 847–853 . November 2000 . 11056398 . 10.1093/oxfordjournals.jbchem.a022823.
