KCNN1 explained

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the K_Ca2.1 protein.^[1]

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The K_Ca2.1 protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. The KCNN1 gene is a member of the KCNN family of potassium channel genes.

See also

• SK channel
• Voltage-gated potassium channel

Further reading

• Wei AD, Gutman GA, Aldrich R, etal . International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels . Pharmacol. Rev. . 57 . 4 . 463–72 . 2006 . 16382103 . 10.1124/pr.57.4.9 . 8290401 .
• Köhler M, Hirschberg B, Bond CT, etal . Small-conductance, calcium-activated potassium channels from mammalian brain . Science . 273 . 5282 . 1709–14 . 1996 . 8781233 . 10.1126/science.273.5282.1709 . 1996Sci...273.1709K . 11603552 .
• Litt M, LaMorticella D, Bond CT, Adelman JP . Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1) . Cytogenet. Cell Genet. . 86 . 1 . 70–3 . 1999 . 10516439 . 10.1159/000015415 . 2024-07-17 . 23461450 .
• Shah M, Haylett DG . The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines . Br. J. Pharmacol. . 129 . 4 . 627–30 . 2000 . 10683185 . 10.1038/sj.bjp.0703111 . 1571896 .
• Liu QH, Williams DA, McManus C, etal . HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation . Proc. Natl. Acad. Sci. U.S.A. . 97 . 9 . 4832–7 . 2000 . 10758170 . 10.1073/pnas.090521697 . 18318 . 2000PNAS...97.4832L . free .
• Rimini R, Rimland JM, Terstappen GC . Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain . Brain Res. Mol. Brain Res. . 85 . 1–2 . 218–20 . 2001 . 11146124 . 10.1016/S0169-328X(00)00255-2 . free .
• Zhang BM, Kohli V, Adachi R, etal . Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicing . Biochemistry . 40 . 10 . 3189–95 . 2001 . 11258935 . 10.1021/bi001675h .
• Boettger MK, Till S, Chen MX, etal . Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors . Brain . 125 . Pt 2 . 252–63 . 2002 . 11844726 . 10.1093/brain/awf026 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Arnold SJ, Facer P, Yiangou Y, etal . Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel . NeuroReport . 14 . 2 . 191–5 . 2003 . 12598727 . 10.1097/00001756-200302100-00006 . 36799012 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Web site: Entrez Gene: KCNN1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1.