KCNK7 explained

Potassium channel, subfamily K, member 7, also known as KCNK7 or K_2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K_2P7.1 is a potassium channel containing two pore-forming P domains.^{[1] [2] [3]} Multiple transcript variants encoding different isoforms have been found for this gene.

Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.^[4]

See also

• Tandem pore domain potassium channel

Further reading

• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N . Potassium leak channels and the KCNK family of two-P-domain subunits . Nat. Rev. Neurosci. . 2 . 3 . 175–84 . 2001 . 11256078 . 10.1038/35058574 . 9682396 .
• Salinas M . Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure . J. Biol. Chem. . 274 . 17 . 11751–60 . 1999 . 10206991 . 10.1074/jbc.274.17.11751 . vanc. Reyes R . Lesage F . 3 . Fosset . M . Heurteaux . C . Romey . G . Lazdunski . M . free .
• Medhurst AD . Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery . Brain Res. Mol. Brain Res. . 86 . 1–2 . 101–14 . 2001 . 11165377 . 10.1016/S0169-328X(00)00263-1 . vanc. Rennie G . Chapman CG . 3 . Meadows . H . Duckworth . MD . Kelsell . RE . Gloger . II . Pangalos . MN .

Notes and References

1. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M . Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure . J. Biol. Chem. . 274 . 17 . 11751–60 . April 1999 . 10206991 . 10.1074/jbc.274.17.11751 . free .
2. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N . Potassium leak channels and the KCNK family of two-P-domain subunits . Nat. Rev. Neurosci. . 2 . 3 . 175–84 . March 2001 . 11256078 . 10.1038/35058574. 9682396 .
3. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S . International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels . Pharmacol. Rev. . 57 . 4 . 527–40 . December 2005 . 16382106 . 10.1124/pr.57.4.12 . 7356601 .
4. Web site: Entrez Gene: potassium channel.