KCNK6 explained

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.^{[1] [2] [3] [4]}

This gene encodes K_2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.

See also

• Tandem pore domain potassium channel

Further reading

• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N . Potassium leak channels and the KCNK family of two-P-domain subunits . Nat. Rev. Neurosci. . 2 . 3 . 175–84 . 2001 . 11256078 . 10.1038/35058574 . 9682396 .
• Mahboubi S, Kaufmann JH . Intramural duodenal hematoma in children. The role of the radiologist in its conservative management . Gastrointestinal Radiology . 1 . 2 . 167–71 . 1978 . 1088718 . 10.1007/BF02256360. 12318832 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Salinas M . Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure . J. Biol. Chem. . 274 . 17 . 11751–60 . 1999 . 10206991 . 10.1074/jbc.274.17.11751 . vanc. Reyes R . Lesage F . 3 . Fosset . M . Heurteaux . C . Romey . G . Lazdunski . M . free .
• Pountney DJ . Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit . FEBS Lett. . 450 . 3 . 191–6 . 1999 . 10359073 . 10.1016/S0014-5793(99)00495-0 . vanc. Gulkarov I . Vega-Saenz de Miera E . 3 . Holmes . D . Saganich . M . Rudy . B . Artman . M . Coetzee . WA . 42980921 . free . 1999FEBSL.450..191P .
• Patel AJ . TWIK-2, an inactivating 2P domain K+ channel . J. Biol. Chem. . 275 . 37 . 28722–30 . 2000 . 10887187 . 10.1074/jbc.M003755200 . vanc. Maingret F . Magnone V . 3 . Fosset . M . Lazdunski . M . Honoré . E . free.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Mhatre AN . Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4 . J. Neurosci. Res. . 75 . 1 . 25–31 . 2004 . 14689445 . 10.1002/jnr.10839 . vanc. Li J . Chen AF . 3 . Yost . C. Spencer . Smith . Richard J.H. . Kindler . Christoph H. . Lalwani . Anil K. . 19133204 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS . TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family . J Biol Chem . 274 . 12 . 7887–92 . Apr 1999 . 10075682 . 10.1074/jbc.274.12.7887 . free .
2. Gray AT, Kindler CH, Sampson ER, Yost CS . Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping . Cytogenet Cell Genet . 84 . 3–4 . 190–1 . Jul 1999 . 10393428 . 10.1159/000015255 . 2024-07-17 . 84538070 .
3. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S . International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels . Pharmacol Rev . 57 . 4 . 527–40 . Dec 2005 . 16382106 . 10.1124/pr.57.4.12 . 7356601 .
4. Web site: Entrez Gene: KCNK6 potassium channel, subfamily K, member 6.