KCNK5 explained

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.^{[1] [2] [3]}

This gene encodes K_2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.

See also

• Tandem pore domain potassium channel

Further reading

• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N . Potassium leak channels and the KCNK family of two-P-domain subunits . Nat. Rev. Neurosci. . 2 . 3 . 175–84 . 2001 . 11256078 . 10.1038/35058574 . 9682396 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Gray AT, Zhao BB, Kindler CH, etal . Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5 . Anesthesiology . 92 . 6 . 1722–30 . 2000 . 10839924 . 10.1097/00000542-200006000-00032 . 45487917 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Morton MJ, O'Connell AD, Sivaprasadarao A, Hunter M . Determinants of pH sensing in the two-pore domain K(+) channels TASK-1 and -2 . Pflügers Arch. . 445 . 5 . 577–83 . 2003 . 12634929 . 10.1007/s00424-002-0901-2 . 6338907 .
• Niemeyer MI, Cid LP, Valenzuela X, etal . Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity . Mol. Membr. Biol. . 20 . 2 . 185–91 . 2004 . 12851074 . 10.1080/0968768031000084181 . 36255147 . 10533/174402 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Rusznák Z, Pocsai K, Kovács I, etal . Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum . Cell. Mol. Life Sci. . 61 . 12 . 1532–42 . 2004 . 15197476 . 10.1007/s00018-004-4082-3 . 11439105 . 11138546 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M . Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney . J Biol Chem . 273 . 47 . 30863–9 . Dec 1998 . 9812978 . 10.1074/jbc.273.47.30863 . free .
2. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S . International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels . Pharmacol Rev . 57 . 4 . 527–40 . Dec 2005 . 16382106 . 10.1124/pr.57.4.12 . 7356601 .
3. Web site: Entrez Gene: KCNK5 potassium channel, subfamily K, member 5.