KCNK17 explained

Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.^{[1] [2]}

This gene encodes K_2P17.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel, primarily expressed in the pancreas, is activated at alkaline pH.

See also

• Tandem pore domain potassium channel

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Girard C, Duprat F, Terrenoire C, etal . Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels . Biochem. Biophys. Res. Commun. . 282 . 1 . 249–56 . 2001 . 11263999 . 10.1006/bbrc.2001.4562 .
• Decher N, Maier M, Dittrich W, etal . Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family . FEBS Lett. . 492 . 1–2 . 84–9 . 2001 . 11248242 . 10.1016/S0014-5793(01)02222-0 . 23620127 . 2001FEBSL.492...84D .

Notes and References

1. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S . International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels . Pharmacol Rev . 57 . 4 . 527–40 . Dec 2005 . 16382106 . 10.1124/pr.57.4.12 . 7356601 .
2. Web site: Entrez Gene: KCNK17 potassium channel, subfamily K, member 17.