KCNK10 explained

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K_2P10.1, is a potassium channel containing two pore-forming P domains.^{[1] [2] [3]}

See also

• Tandem pore domain potassium channel

Further reading

• Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, Daut J . Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2 . The Journal of Physiology . 539 . Pt 3 . 657–68 . March 2002 . 11897838 . 2290188 . 10.1113/jphysiol.2001.013432 .
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N . Potassium leak channels and the KCNK family of two-P-domain subunits . Nature Reviews. Neuroscience . 2 . 3 . 175–84 . March 2001 . 11256078 . 10.1038/35058574 . 9682396 .
• Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D . Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein . British Journal of Pharmacology . 154 . 8 . 1680–90 . August 2008 . 18516069 . 2518462 . 10.1038/bjp.2008.213 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . April 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . April 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Bang H, Kim Y, Kim D . TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family . The Journal of Biological Chemistry . 275 . 23 . 17412–9 . June 2000 . 10747911 . 10.1074/jbc.M000445200 . free .

Notes and References

1. Lesage F, Terrenoire C, Romey G, Lazdunski M . Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors . The Journal of Biological Chemistry . 275 . 37 . 28398–405 . September 2000 . 10880510 . 10.1074/jbc.M002822200 . free .
2. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S . International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels . Pharmacological Reviews . 57 . 4 . 527–40 . December 2005 . 16382106 . 10.1124/pr.57.4.12 . 7356601 .
3. Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP . K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac . Science . 347 . 6227 . 1256–9 . March 2015 . 25766236 . 10.1126/science.1261512 . 6034649 . 2015Sci...347.1256D .