KCNK1 explained

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.^{[1] [2] [3]}

This gene encodes K_2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.

See also

• Tandem pore domain potassium channel

Further reading

• Goldstein SA, Wang KW, Ilan N, Pausch MH . Sequence and function of the two P domain potassium channels: implications of an emerging superfamily . J. Mol. Med. . 76 . 1 . 13–20 . 1998 . 9462864 . 10.1007/s109-1998-8100-0 .
• Lesage F, Lazdunski M . Molecular and functional properties of two-pore-domain potassium channels . Am. J. Physiol. Renal Physiol. . 279 . 5 . F793–801 . 2000 . 11053038 . 10.1152/ajprenal.2000.279.5.F793. 16605017 .
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N . Potassium leak channels and the KCNK family of two-P-domain subunits . Nat. Rev. Neurosci. . 2 . 3 . 175–84 . 2001 . 11256078 . 10.1038/35058574 . 9682396 .
• Lesage F . TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure . EMBO J. . 15 . 5 . 1004–11 . 1996 . 8605869 . 10.1002/j.1460-2075.1996.tb00437.x. 449995 . vanc. Guillemare E . Fink M . 3 . Duprat . F . Lazdunski . M . Romey . G . Barhanin . J .
• Lesage F . Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge . EMBO J. . 15 . 23 . 6400–7 . 1997 . 8978667 . 10.1002/j.1460-2075.1996.tb01031.x. 452465 . vanc. Reyes R . Fink M . 3 . Duprat . F . Guillemare . E . Lazdunski . M .
• Orias M . Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments . Am. J. Physiol. . 273 . 4 Pt 2 . F663–6 . 1997 . 9362344 . 10.1152/ajprenal.1997.273.4.F663. vanc. Velázquez H . Tung F . 3 . Lee . G . Desir . GV .
• Wang Z . Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle . Circulation . 98 . 22 . 2422–8 . 1999 . 9832487 . 10.1161/01.cir.98.22.2422. vanc. Yue L . White M . 3 . Pelletier . G . Nattel . S . free.
• Medhurst AD . Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery . Brain Res. Mol. Brain Res. . 86 . 1–2 . 101–14 . 2001 . 11165377 . 10.1016/S0169-328X(00)00263-1 . vanc. Rennie G . Chapman CG . 3 . Meadows . H . Duckworth . MD . Kelsell . RE . Gloger . II . Pangalos . MN .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Nicolas MT, Barhanin J, Reyes R, Demêmes D . Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear . Hear. Res. . 181 . 1–2 . 20–6 . 2004 . 12855359 . 10.1016/S0378-5955(03)00162-X . 23605830 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rajan S . Sumoylation silences the plasma membrane leak K+ channel K2P1 . Cell . 121 . 1 . 37–47 . 2005 . 15820677 . 10.1016/j.cell.2005.01.019 . vanc. Plant LD . Rabin ML . 3 . Butler . Margaret H. . Goldstein . Steve A.N. . 6314155 . free .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M . Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43 . Genomics . 34 . 1 . 153–5 . Dec 1996 . 8661042 . 10.1006/geno.1996.0259 .
2. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S . International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels . Pharmacol Rev . 57 . 4 . 527–40 . Dec 2005 . 16382106 . 10.1124/pr.57.4.12 . 7356601 .
3. Web site: Entrez Gene: KCNK1 potassium channel, subfamily K, member 1.