KCNIP4 explained

Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene.^{[1] [2] [3]}

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily.^[4] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Interactions

KCNIP4 has been shown to interact with PSEN2.

See also

• Voltage-gated potassium channel

Further reading

• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Lin YL, Lin SR, Wu TT, Chang LS . Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins . Biochem. Biophys. Res. Commun. . 319 . 3 . 720–4 . 2004 . 15184042 . 10.1016/j.bbrc.2004.05.064 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Hillier LW . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . Graves TA . Fulton RS . 3 . Fulton . Lucinda A. . Pepin . Kymberlie H. . Minx . Patrick . Wagner-Mcpherson . Caryn . Layman . Dan . Wylie . Kristine . 2005Natur.434..724H . free .
• Pruunsild P, Timmusk T . Structure, alternative splicing, and expression of the human and mouse KCNIP gene family . Genomics . 86 . 5 . 581–93 . 2005 . 16112838 . 10.1016/j.ygeno.2005.07.001 .
• Chen CP, Lee L, Chang LS . Effects of metal-binding properties of human Kv channel-interacting proteins on their molecular structure and binding with Kv4.2 channel . Protein J. . 25 . 5 . 345–51 . 2007 . 16951992 . 10.1007/s10930-006-9020-9 . 43400673 .
• Ewing RM . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .
• Bonne A . Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene . Cancer Genet. Cytogenet. . 179 . 1 . 11–8 . 2008 . 17981209 . 10.1016/j.cancergencyto.2007.07.005 . Vreede L . Kuiper RP . 3 . Bodmer . D . Jansen . C . Eleveld . M . Vanerp . F . Arkesteijn . G . Hoogerbrugge . N .

Notes and References

1. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF . Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain . Proc Natl Acad Sci U S A . 99 . 2 . 1035–40 . Jan 2002 . 11805342 . 117799 . 10.1073/pnas.022509299 . 2002PNAS...99.1035H . free .
2. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T . Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4 . J Biol Chem . 277 . 17 . 14965–75 . Apr 2002 . 11847232 . 10.1074/jbc.M200897200 . free .
3. Web site: Entrez Gene: KCNIP4 Kv channel interacting protein 4.
4. Burgoyne RD. Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat. Rev. Neurosci. . 8 . 3 . 182–193 . 2007 . 17311005 . 1887812 . 10.1038/nrn2093 .