KCNIP1 explained

K_v channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.^{[1] [2]}

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.

See also

• Voltage-gated potassium channel

Further reading

• Bähring R . Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating . J. Biol. Chem. . 276 . 26 . 23888–23894 . 2001 . 11287421 . 10.1074/jbc.M101320200 . vanc. Dannenberg J . Peters HC . 3 . Leicher . T . Pongs . O . Isbrandt . D . free.
• Nakamura TY . Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2 . FEBS Lett. . 499 . 3 . 205–209 . 2001 . 11423117 . 10.1016/S0014-5793(01)02560-1 . vanc. Nandi S . Pountney DJ . 3 . Artman . M . Rudy . B . Coetzee . WA . 23908034 . free. 2001FEBSL.499..205N .
• Kutsenko AS . NotI flanking sequences: a tool for gene discovery and verification of the human genome . Nucleic Acids Res. . 30 . 14 . 3163–3170 . 2002 . 12136098 . 10.1093/nar/gkf428 . 135748 . vanc. Gizatullin RZ . Al-Amin AN . 3 . Wang . F . Kvasha . SM . Podowski . RM . Matushkin . YG . Gyanchandani . A . Muravenko . OV .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Shibata R . A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels . J. Biol. Chem. . 278 . 38 . 36445–36454 . 2003 . 12829703 . 10.1074/jbc.M306142200 . vanc. Misonou H . Campomanes CR . 3 . Anderson . AE . Schrader . LA . Doliveira . LC . Carroll . KI . Sweatt . JD . Rhodes . KJ . free .
• Van Hoorick D . Differential modulation of Kv4 kinetics by KCHIP1 splice variants . Mol. Cell. Neurosci. . 24 . 2 . 357–366 . 2004 . 14572458 . 10.1016/S1044-7431(03)00174-X . vanc. Raes A . Keysers W . 3 . Mayeur . E . Snyders . DJ . 40647616 .
• Scannevin RH . Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1 . Neuron . 41 . 4 . 587–598 . 2004 . 14980207 . 10.1016/S0896-6273(04)00049-2 . vanc. Wang K . Jow F . 3 . Megules . Jennifer . Kopsco . David C . Edris . Wade . Carroll . Karen C . Lü . Qiang . Xu . Weixin . 17380435 . free .
• Lin YL, Lin SR, Wu TT, Chang LS . Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins . Biochem. Biophys. Res. Commun. . 319 . 3 . 720–724 . 2004 . 15184042 . 10.1016/j.bbrc.2004.05.064 .
• Lin YL, Chen CY, Cheng CP, Chang LS . Protein-protein interactions of KChIP proteins and Kv4.2 . Biochem. Biophys. Res. Commun. . 321 . 3 . 606–610 . 2004 . 15358149 . 10.1016/j.bbrc.2004.07.006 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Pruunsild P, Timmusk T . Structure, alternative splicing, and expression of the human and mouse KCNIP gene family . Genomics . 86 . 5 . 581–593 . 2005 . 16112838 . 10.1016/j.ygeno.2005.07.001 .
• Pioletti M, Findeisen F, Hura GL, Minor DL . Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer . Nat. Struct. Mol. Biol. . 13 . 11 . 987–995 . 2007 . 17057713 . 10.1038/nsmb1164 . Minor . 3018330 .
• 10.1083/jcb.200506005 . Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD . Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway . J. Cell Biol. . 171 . 3 . 459–469 . 2005 . 16260497 . 2171252 .
• 10.1042/BJ20080441 . Venn N, Haynes LP, Burgoyne RD . Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells . Biochem. J. . 413 . 1 . 71–80 . 2008 . 18393943 . 2474559 .

Notes and References

1. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ . Modulation of A-type potassium channels by a family of calcium sensors . Nature . 403 . 6769 . 553–556 . Feb 2000 . 10676964 . 10.1038/35000592 . 2000Natur.403..553A . 4419472 .
2. Web site: Entrez Gene: KCNIP1 Kv channel interacting protein 1.
3. Burgoyne RD. Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat. Rev. Neurosci. . 8 . 3 . 182–193 . 2007 . 17311005 . 1887812 . 10.1038/nrn2093 .