KCND1 explained

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as K_v4.1, is a human gene.^[1]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.^[2]

See also

• Voltage-gated potassium channel

Further reading

• Gutman GA, Chandy KG, Grissmer S, etal . International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. . Pharmacol. Rev. . 57 . 4 . 473–508 . 2006 . 16382104 . 10.1124/pr.57.4.10 . 219195192 .
• Kurschner C, Yuzaki M . Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. . J. Neurosci. . 19 . 18 . 7770–80 . 1999 . 10479680 . 10.1523/JNEUROSCI.19-18-07770.1999. 6782450 . free .
• Isbrandt D, Leicher T, Waldschütz R, etal . Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). . Genomics . 64 . 2 . 144–54 . 2000 . 10729221 . 10.1006/geno.2000.6117 .
• Nakamura TY, Nandi S, Pountney DJ, etal . Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. . FEBS Lett. . 499 . 3 . 205–9 . 2001 . 11423117 . 10.1016/S0014-5793(01)02560-1 . free . 2001FEBSL.499..205N .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Jerng HH, Qian Y, Pfaffinger PJ . Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). . Biophys. J. . 87 . 4 . 2380–96 . 2005 . 15454437 . 10.1529/biophysj.104.042358 . 1304660 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kim SJ, Choi WS, Han JS, etal . A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis. . J. Biol. Chem. . 280 . 31 . 28692–700 . 2005 . 15955806 . 10.1074/jbc.M504913200 . free .

Notes and References

1. Web site: Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1.
2. Web site: Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1.