KCNC4 explained

Potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), also known as K_v3.4, is a human gene.^[1]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene.^[2]

See also

• Voltage-gated potassium channel

Further reading

• Gutman GA, Chandy KG, Grissmer S, etal . International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. . Pharmacol. Rev. . 57 . 4 . 473–508 . 2006 . 16382104 . 10.1124/pr.57.4.10 . 219195192 .
• Vega-Saenz de Miera E, Moreno H, Fruhling D, etal . Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel. . Proc. Biol. Sci. . 248 . 1321 . 9–18 . 1992 . 1381835 . 10.1098/rspb.1992.0036 . 1992RSPSB.248....9V . 8968480 .
• Ghanshani S, Pak M, McPherson JD, etal . Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. . Genomics . 12 . 2 . 190–6 . 1992 . 1740329 . 10.1016/0888-7543(92)90365-Y .
• Rudy B, Sen K, Vega-Saenz de Miera E, etal . Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21. . J. Neurosci. Res. . 29 . 3 . 401–12 . 1991 . 1920536 . 10.1002/jnr.490290316 . 27662306 .
• Covarrubias M, Wei A, Salkoff L, Vyas TB . Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate. . Neuron . 13 . 6 . 1403–12 . 1995 . 7993631 . 10.1016/0896-6273(94)90425-1 . 2211371 .
• Beck EJ, Sorensen RG, Slater SJ, Covarrubias M . Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action. . J. Gen. Physiol. . 112 . 1 . 71–84 . 1998 . 9649584 . 10.1085/jgp.112.1.71 . 2229409 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Angulo E, Noé V, Casadó V, etal . Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. . J. Neurochem. . 91 . 3 . 547–57 . 2005 . 15485486 . 10.1111/j.1471-4159.2004.02771.x . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Abbott GW, Butler MH, Goldstein SA . Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. . FASEB J. . 20 . 2 . 293–301 . 2006 . 16449802 . 10.1096/fj.05-5070com . free . 21538479 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .

Notes and References

1. Web site: Entrez Gene: KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4.
2. Web site: Entrez Gene: KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4.