KCNC2 explained

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.[1] [2] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).[3]

Expression pattern

Kv3.1 and Kv3.2 channels are prominently expressed in neurons that fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.[4] [5] [3]

Physiological role

Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[6] Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.[3] [4]

Pharmacological properties

Kv3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC50 values are 0.1 mM for both of the drugs).[3] This can be useful in identifying native channels.[5]

Transcript variants

There are four transcript variants of Kv3.2 gene: Kv3.2a, Kv3.2b, Kv3.2c, Kv3.2d. Kv3.2 isoforms differ only in their C-terminal sequence.[7]

Notes and References

  1. Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B . Localization of Shaw-related K+ channel genes on mouse and human chromosomes . Mamm Genome . 4 . 12 . 711–5 . Mar 1994 . 8111118 . 10.1007/BF00357794 . 24121259 .
  2. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X . International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels . Pharmacol Rev . 57 . 4 . 473–508 . Dec 2005 . 16382104 . 10.1124/pr.57.4.10 . 219195192 .
  3. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X . International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels . Pharmacol. Rev. . 57 . 4 . 473–508 . December 2005 . 16382104 . 10.1124/pr.57.4.10 . 219195192 .
  4. Web site: Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat . Kolodin YO . 2008-04-27 . 2008-10-20.
  5. Rudy B, McBain CJ . Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing . Trends in Neurosciences . 24 . 9 . 517–26 . September 2001 . 11506885 . 10.1016/S0166-2236(00)01892-0 . 36100588 .
  6. Lien CC, Jonas P . Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons . Journal of Neuroscience . 23 . 6 . 2058–68 . March 2003 . 12657664 . 10.1523/JNEUROSCI.23-06-02058.2003. 6742035 . free .
  7. Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E . Contributions of Kv3 channels to neuronal excitability . Annals of the New York Academy of Sciences . 868 . 1 MOLECULAR AND. 304–43 . April 1999 . 10414303 . 10.1111/j.1749-6632.1999.tb11295.x . 25289187 . free . 1999NYASA.868..304R .

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