KCNAB2 explained

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.^{[1] [2]}

Function

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.^[2]

In melanocytic cells KCNAB2 gene expression may be regulated by MITF.^[3]

Interactions

KCNAB2 has been shown to interact with KCNA2.^{[4] [5]}

See also

• Voltage-gated potassium channel

Further reading

• McCormack K, McCormack T, Tanouye M, Rudy B, Stühmer W . Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. . FEBS Lett. . 370 . 1–2 . 32–6 . 1995 . 7649300 . 10.1016/0014-5793(95)00785-8 . free . 1995FEBSL.370...32M .
• McCormack T, McCormack K . Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. . Cell . 79 . 7 . 1133–5 . 1995 . 8001150 . 10.1016/0092-8674(94)90004-3 . 10080280 .
• Nakahira K, Shi G, Rhodes KJ, Trimmer JS . Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. . J. Biol. Chem. . 271 . 12 . 7084–9 . 1996 . 8636142 . 10.1074/jbc.271.12.7084 . free .
• Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF . Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. . Circulation . 98 . 14 . 1383–93 . 1998 . 9760292 . 10.1161/01.cir.98.14.1383 . free .
• Coleman SK, Newcombe J, Pryke J, Dolly JO . Subunit composition of Kv1 channels in human CNS. . J. Neurochem. . 73 . 2 . 849–58 . 1999 . 10428084 . 10.1046/j.1471-4159.1999.0730849.x . free .
• Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E . Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. . Neuron . 24 . 4 . 1037–47 . 2000 . 10624965 . 10.1016/S0896-6273(00)81049-1 . 12444497 . free .
• Croci C, Brändstatter JH, Enz R . ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. . J. Biol. Chem. . 278 . 8 . 6128–35 . 2003 . 12431995 . 10.1074/jbc.M205162200 . free .
• Gu C, Jan YN, Jan LY . A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. . Science . 301 . 5633 . 646–9 . 2003 . 12893943 . 10.1126/science.1086998 . 2003Sci...301..646G . 9924760 .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Huda Zoghbi . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Schultz D, Litt M, Smith L, Thayer M, McCormack K . Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B . Genomics . 31 . 3 . 389–91 . Mar 1997 . 8838324 . 10.1006/geno.1996.0065 .
2. Web site: Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2.
3. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res. . 21 . 6 . 665–76 . 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . free .
4. Coleman SK, Newcombe J, Pryke J, Dolly JO . Subunit composition of Kv1 channels in human CNS . J. Neurochem. . 73 . 2 . 849–58 . Aug 1999 . 10428084 . 10.1046/j.1471-4159.1999.0730849.x . free .
5. Nakahira K, Shi G, Rhodes KJ, Trimmer JS . Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits . J. Biol. Chem. . 271 . 12 . 7084–9 . Mar 1996 . 8636142 . 10.1074/jbc.271.12.7084 . free .