KCNAB1 explained

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.^{[1] [2] [3]}

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms that are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.

See also

• Voltage-gated potassium channel

Further reading

• England SK, Uebele VN, Shear H, etal . Characterization of a voltage-gated K+ channel beta subunit expressed in human heart . Proc. Natl. Acad. Sci. U.S.A. . 92 . 14 . 6309–13 . 1995 . 7603988 . 10.1073/pnas.92.14.6309 . 41507 . 1995PNAS...92.6309E . free .
• McCormack K, McCormack T, Tanouye M, etal . Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product . FEBS Lett. . 370 . 1–2 . 32–6 . 1995 . 7649300 . 10.1016/0014-5793(95)00785-8 . 83802327 . free . 1995FEBSL.370...32M .
• Majumder K, De Biasi M, Wang Z, Wible BA . Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium . FEBS Lett. . 361 . 1 . 13–6 . 1995 . 7890032 . 10.1016/0014-5793(95)00120-X . 24227365 . free . 1995FEBSL.361...13M .
• Morales MJ, Castellino RC, Crews AL, etal . A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits . J. Biol. Chem. . 270 . 11 . 6272–7 . 1995 . 7890764 . 10.1074/jbc.270.11.6272 . free .
• McCormack T, McCormack K . Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily . Cell . 79 . 7 . 1133–5 . 1995 . 8001150 . 10.1016/0092-8674(94)90004-3 . 10080280 .
• Nakahira K, Shi G, Rhodes KJ, Trimmer JS . Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits . J. Biol. Chem. . 271 . 12 . 7084–9 . 1996 . 8636142 . 10.1074/jbc.271.12.7084 . free .
• Leicher T, Roeper J, Weber K, etal . Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B) . Neuropharmacology . 35 . 7 . 787–95 . 1997 . 8938711 . 10.1016/0028-3908(96)00133-5 . 53297655 .
• Hanada T, Lin L, Chandy KG, etal . Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes . J. Biol. Chem. . 272 . 43 . 26899–904 . 1997 . 9341123 . 10.1074/jbc.272.43.26899 . free .
• Leicher T, Bähring R, Isbrandt D, Pongs O . Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel . J. Biol. Chem. . 273 . 52 . 35095–101 . 1999 . 9857044 . 10.1074/jbc.273.52.35095 . free .
• Suzuki Y, Ishihara D, Sasaki M, etal . Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries . Genomics . 64 . 3 . 286–97 . 2000 . 10756096 . 10.1006/geno.2000.6076 .
• Kuryshev YA, Wible BA, Gudz TI, etal . KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression . Am. J. Physiol., Cell Physiol. . 281 . 1 . C290–9 . 2001 . 11401852 . 10.1152/ajpcell.2001.281.1.c290. 2308556 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nie DY, Zhou ZH, Ang BT, etal . Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K+ channel localization . EMBO J. . 22 . 21 . 5666–78 . 2003 . 14592966 . 10.1093/emboj/cdg570 . 275427 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Schultz D, Litt M, Smith L, Thayer M, McCormack K . Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B . Genomics . 31 . 3 . 389–91 . Mar 1997 . 8838324 . 10.1006/geno.1996.0065 .
2. England SK, Uebele VN, Kodali J, Bennett PB, Tamkun MM . A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing . J Biol Chem . 270 . 48 . 28531–4 . Jan 1996 . 7499366 . 10.1074/jbc.270.48.28531 . free .
3. Web site: Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1.