KCNA7 explained

Potassium voltage-gated channel subfamily A member 7 also known as K_v1.7 is a protein that in humans is encoded by the KCNA7 gene.^[1] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[2]

Further reading

• Kashuba VI, Kvasha SM, Protopopov AI, etal . Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. . Gene . 268 . 1–2 . 115–22 . 2001 . 11368907 . 10.1016/S0378-1119(01)00423-1 .
• Kalman K, Nguyen A, Tseng-Crank J, etal . Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7 . J. Biol. Chem. . 273 . 10 . 5851–7 . 1998 . 9488722 . 10.1074/jbc.273.10.5851 . free .
• Ding Q, Zhao YY, Dong LY, etal . [Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China] . Yi Chuan . 25 . 2 . 129–32 . 2003 . 15639836 .
• Bardien-Kruger S, Wulff H, Arieff Z, etal . Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI) . Eur. J. Hum. Genet. . 10 . 1 . 36–43 . 2002 . 11896454 . 10.1038/sj.ejhg.5200739 . 8333189 .

Notes and References

1. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X . International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels . Pharmacol Rev . 57 . 4 . 473–508 . Dec 2005 . 16382104 . 10.1124/pr.57.4.10 . 219195192 .
2. Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH . The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium . J. Mol. Cell. Cardiol. . 33 . 5 . 851–72 . May 2001 . 11343410 . 10.1006/jmcc.2001.1376 .