KATNB1 explained

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.^{[1] [2]}

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.^[3] KATNB1 is associated with microlissencephaly.

Further reading

• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Toyo-Oka K, Sasaki S, Yano Y, etal . Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. . Hum. Mol. Genet. . 14 . 21 . 3113–28 . 2006 . 16203747 . 10.1093/hmg/ddi339 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Karabay A, Yu W, Solowska JM, etal . Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. . J. Neurosci. . 24 . 25 . 5778–88 . 2004 . 15215300 . 10.1523/JNEUROSCI.1382-04.2004 . 6729225 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• McNally KP, Bazirgan OA, McNally FJ . Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. . J. Cell Sci. . 113 . 9. 1623–33 . 2000 . 10.1242/jcs.113.9.1623 . 10751153 .
• Ahmad FJ, Yu W, McNally FJ, Baas PW . An essential role for katanin in severing microtubules in the neuron. . J. Cell Biol. . 145 . 2 . 305–15 . 1999 . 10209026 . 10.1083/jcb.145.2.305 . 2133110 .
• McNally FJ, Thomas S . Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. . Mol. Biol. Cell . 9 . 7 . 1847–61 . 1999 . 9658175 . 10.1091/mbc.9.7.1847. 25426 .
• McNally FJ, Okawa K, Iwamatsu A, Vale RD . Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. . J. Cell Sci. . 109 . 3. 561–7 . 1997 . 10.1242/jcs.109.3.561 . 8907702 .
• McNally FJ, Vale RD . Identification of katanin, an ATPase that severs and disassembles stable microtubules. . Cell . 75 . 3 . 419–29 . 1993 . 8221885 . 10.1016/0092-8674(93)90377-3 . 10264319 .
• Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW . Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. . Mol. Cell. Biol. . 3 . 10 . 1738–45 . 1984 . 6646120 . 10.1128/mcb.3.10.1738. 370035 .

Notes and References

1. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ . Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit . Cell . 93 . 2 . 277–87 . May 1998 . 9568719 . 10.1016/S0092-8674(00)81578-0 . 13583382 . free .
2. Web site: Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1.
3. Web site: Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1.