KATNA1 explained

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.^{[1] [2]}

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.^[3]

Further reading

• McNally FJ, Vale RD . Identification of katanin, an ATPase that severs and disassembles stable microtubules. . Cell . 75 . 3 . 419–29 . 1993 . 8221885 . 10.1016/0092-8674(93)90377-3 . 10264319 .
• McNally FJ, Okawa K, Iwamatsu A, Vale RD . Katanin, the microtubule-severing ATPase, is concentrated at centrosomes. . J. Cell Sci. . 109 . 3. 561–7 . 1997 . 10.1242/jcs.109.3.561 . 8907702 .
• Hartman JJ, Mahr J, McNally K, etal . Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. . Cell . 93 . 2 . 277–87 . 1998 . 9568719 . 10.1016/S0092-8674(00)81578-0 . 13583382 . free .
• Ahmad FJ, Yu W, McNally FJ, Baas PW . An essential role for katanin in severing microtubules in the neuron. . J. Cell Biol. . 145 . 2 . 305–15 . 1999 . 10209026 . 10.1083/jcb.145.2.305 . 2133110 .
• Syu LJ, Saltiel AR . Lipotransin: a novel docking protein for hormone-sensitive lipase. . Mol. Cell . 4 . 1 . 109–15 . 1999 . 10445032 . 10.1016/S1097-2765(00)80192-6 . free .
• McNally KP, Bazirgan OA, McNally FJ . Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. . J. Cell Sci. . 113 . 9. 1623–33 . 2000 . 10.1242/jcs.113.9.1623 . 10751153 .
• Buster D, McNally K, McNally FJ . Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis. . J. Cell Sci. . 115 . Pt 5 . 1083–92 . 2002 . 10.1242/jcs.115.5.1083 . 11870226 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. McNally FJ, Thomas S . Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs . Mol Biol Cell . 9 . 7 . 1847–61 . Jan 1999 . 9658175 . 25426 . 10.1091/mbc.9.7.1847.
2. Web site: Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1.
3. Web site: Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1.