KAT7 (gene) explained

Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene.^{[1] [2] [3]} It specifically acetylates H4 histones at the lysine12 residue (H4K12)^[4] and is necessary for origin licensing and DNA replication.^{[5] [6]} KAT7 associates with origins of replication during G1 phase of the cell cycle through complexing with CDT1.^[7] Geminin is thought to inhibit the acetyltransferase activity of KAT7 when KAT7 and CDT1 are complexed together.^[8]

Interactions

KAT7 has been shown to interact with:

• AR,
• CDT1,
• MCM2^[9]
• ORC1L and
• VIM,^{[10] [11]}

Further reading

• Kueh AJ, Dixon MP, Voss AK, Thomas T . HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development . Molecular and Cellular Biology . 31 . 4 . 845–60 . Feb 2011 . 21149574 . 10.1128/MCB.00159-10 . 3028655.
• Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M . The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing . The Journal of Biological Chemistry . 277 . 28 . 25026–31 . Jul 2002 . 11978794 . 10.1074/jbc.M202256200 . free .
• Sharma D, Fondell JD . Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo . Proceedings of the National Academy of Sciences of the United States of America . 99 . 12 . 7934–9 . Jun 2002 . 12034878 . 122998 . 10.1073/pnas.122004799 . 2002PNAS...99.7934S . free .
• Bernhard Landwehrmeyer. Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE . A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease . Molecular Cell . 15 . 6 . 853–65 . Sep 2004 . 15383276 . 10.1016/j.molcel.2004.09.016 . free .
• Zong H, Li Z, Liu L, Hong Y, Yun X, Jiang J, Chi Y, Wang H, Shen X, Hu Y, Niu Z, Gu J . Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity . FEBS Letters . 579 . 17 . 3579–88 . Jul 2005 . 15963510 . 10.1016/j.febslet.2005.05.039 . 23462168 . free .
• Cereseto A, Manganaro L, Gutierrez MI, Terreni M, Fittipaldi A, Lusic M, Marcello A, Giacca M . Acetylation of HIV-1 integrase by p300 regulates viral integration . The EMBO Journal . 24 . 17 . 3070–81 . Sep 2005 . 16096645 . 1201351 . 10.1038/sj.emboj.7600770 .
• Georgiakaki M, Chabbert-Buffet N, Dasen B, Meduri G, Wenk S, Rajhi L, Amazit L, Chauchereau A, Burger CW, Blok LJ, Milgrom E, Lombès M, Guiochon-Mantel A, Loosfelt H . Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription . Molecular Endocrinology . 20 . 9 . 2122–40 . Sep 2006 . 16645042 . 10.1210/me.2005-0149 . 9870877 . free .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . Oct 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Topper M, Luo Y, Zhadina M, Mohammed K, Smith L, Muesing MA . Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication . Journal of Virology . 81 . 6 . 3012–7 . Mar 2007 . 17182677 . 1865993 . 10.1128/JVI.02257-06 .

Notes and References

1. Iizuka M, Stillman B . Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein . The Journal of Biological Chemistry . 274 . 33 . 23027–34 . Aug 1999 . 10438470 . 10.1074/jbc.274.33.23027 . free .
2. Sharma M, Zarnegar M, Li X, Lim B, Sun Z . Androgen receptor interacts with a novel MYST protein, HBO1 . The Journal of Biological Chemistry . 275 . 45 . 35200–8 . Nov 2000 . 10930412 . 10.1074/jbc.M004838200 . free .
3. Web site: Entrez Gene: MYST2 MYST histone acetyltransferase 2.
4. Sterner DE, Berger SL . Acetylation of histones and transcription-related factors . Microbiology and Molecular Biology Reviews . 64 . 2 . 435–59 . Jun 2000 . 10839822 . 98999 . 10.1128/mmbr.64.2.435-459.2000.
5. Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J . ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation . Molecular Cell . 21 . 1 . 51–64 . Jan 2006 . 16387653 . 10.1016/j.molcel.2005.12.007 . free .
6. Iizuka M, Matsui T, Takisawa H, Smith MM . Regulation of replication licensing by acetyltransferase Hbo1 . Molecular and Cellular Biology . 26 . 3 . 1098–108 . Feb 2006 . 16428461 . 1347032 . 10.1128/MCB.26.3.1098-1108.2006 .
7. Miotto B, Struhl K . HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1 . Genes & Development . 22 . 19 . 2633–8 . Oct 2008 . 18832067 . 2559906 . 10.1101/gad.1674108 .
8. Miotto B, Struhl K . HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin . Molecular Cell . 37 . 1 . 57–66 . Jan 2010 . 20129055 . 2818871 . 10.1016/j.molcel.2009.12.012 .
9. Burke TW, Cook JG, Asano M, Nevins JR . Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1 . The Journal of Biological Chemistry . 276 . 18 . 15397–408 . May 2001 . 11278932 . 10.1074/jbc.M011556200 . free .
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
11. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .