CD82 (gene) explained

CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the gene.^[1]

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Interactions

CD82 (gene) has been shown to interact with CD19,^{[2] [3]} CD63^[4] and CD234.^[5]

CD82 plays a key role in the development of endometriosis.^[6]

See also

• Cluster of differentiation

Further reading

• Baek SH . A novel link between SUMO modification and cancer metastasis . Cell Cycle . 5 . 14 . 1492–5 . July 2006 . 16861889 . 10.4161/cc.5.14.3008 . free .
• Imai T, Fukudome K, Takagi S, Nagira M, Furuse M, Fukuhara N, Nishimura M, Hinuma Y, Yoshie O . 6 . C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63 . Journal of Immunology . 149 . 9 . 2879–86 . November 1992 . 10.4049/jimmunol.149.9.2879 . 1401919 . 21935007 .
• Ichikawa T, Ichikawa Y, Dong J, Hawkins AL, Griffin CA, Isaacs WB, Oshimura M, Barrett JC, Isaacs JT . 6 . Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11 . Cancer Research . 52 . 12 . 3486–90 . June 1992 . 1596907 .
• Gaugitsch HW, Hofer E, Huber NE, Schnabl E, Baumruker T . A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23 . European Journal of Immunology . 21 . 2 . 377–83 . February 1991 . 1842498 . 10.1002/eji.1830210219 . 423800 .
• Ichikawa T, Ichikawa Y, Isaacs JT . Genetic factors and suppression of metastatic ability of prostatic cancer . Cancer Research . 51 . 14 . 3788–92 . July 1991 . 2065333 .
• Imai T, Kakizaki M, Nishimura M, Yoshie O . Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82 . Journal of Immunology . 155 . 3 . 1229–39 . August 1995 . 10.4049/jimmunol.155.3.1229 . 7636191 . 32942467 .
• Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC . KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2 . Science . 268 . 5212 . 884–6 . May 1995 . 7754374 . 10.1126/science.7754374 . 1995Sci...268..884D .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME . Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29) . Journal of Immunology . 157 . 5 . 2039–47 . September 1996 . 10.4049/jimmunol.157.5.2039 . 8757325 . free .
• Szöllósi J, Horejsí V, Bene L, Angelisová P, Damjanovich S . Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY . Journal of Immunology . 157 . 7 . 2939–46 . October 1996 . 10.4049/jimmunol.157.7.2939 . 8816400 . free .
• Dong JT, Isaacs WB, Barrett JC, Isaacs JT . Genomic organization of the human KAI1 metastasis-suppressor gene . Genomics . 41 . 1 . 25–32 . April 1997 . 9126478 . 10.1006/geno.1997.4618 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P . The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules . Journal of Immunology . 161 . 7 . 3282–91 . October 1998 . 10.4049/jimmunol.161.7.3282 . 9759843 . free .
• Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E . CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82 . The Journal of Biological Chemistry . 273 . 46 . 30537–43 . November 1998 . 9804823 . 10.1074/jbc.273.46.30537 . free .
• Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E . Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions . The Biochemical Journal . 340 (Pt 1) . 1 . 103–11 . May 1999 . 10229664 . 1220227 . 10.1042/0264-6021:3400103 .
• Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC . Loss of KAI1 expression in the progression of colorectal cancer . Cancer Research . 59 . 22 . 5724–31 . November 1999 . 10582691 .
• Shibagaki N, Hanada K, Yamashita H, Shimada S, Hamada H . Overexpression of CD82 on human T cells enhances LFA-1 / ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T cell activation . European Journal of Immunology . 29 . 12 . 4081–91 . December 1999 . 10602019 . 10.1002/(SICI)1521-4141(199912)29:12<4081::AID-IMMU4081>3.0.CO;2-I . free .
• Nakamura K, Mitamura T, Takahashi T, Kobayashi T, Mekada E . Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity . The Journal of Biological Chemistry . 275 . 24 . 18284–90 . June 2000 . 10749879 . 10.1074/jbc.M907971199 . free .
• Odintsova E, Sugiura T, Berditchevski F . Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1 . Current Biology . 10 . 16 . 1009–12 . August 2000 . 10985391 . 10.1016/S0960-9822(00)00652-7 . 15731587 . free .
• Ono M, Handa K, Withers DA, Hakomori S . Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells . Biochemical and Biophysical Research Communications . 279 . 3 . 744–50 . December 2000 . 11162423 . 10.1006/bbrc.2000.4030 . Sen-itiroh Hakomori .

Notes and References

1. Web site: Entrez Gene: CD82 CD82 molecule.
2. Imai T, Kakizaki M, Nishimura M, Yoshie O . Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82 . Journal of Immunology . 155 . 3 . 1229–39 . August 1995 . 10.4049/jimmunol.155.3.1229 . 7636191 . 32942467 .
3. Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E . CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82 . The Journal of Biological Chemistry . 273 . 46 . 30537–43 . November 1998 . 9804823 . 10.1074/jbc.273.46.30537 . free .
4. Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P . The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules . Journal of Immunology . 161 . 7 . 3282–91 . October 1998 . 10.4049/jimmunol.161.7.3282 . 9759843 . free .
5. Hur J, Choi JI, Lee H, Nham P, Kim TW, Chae CW, Yun JY, Kang JA, Kang J, Lee SE, Yoon CH, Boo K, Ham S, Roh TY, Jun JK, Lee H, Baek SH, Kim HS . 6 . CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages . Cell Stem Cell . 18 . 4 . 508–21 . April 2016 . 26996598 . 10.1016/j.stem.2016.01.013 . free .
6. Timologou . A . Zafrakas M . Grimbizis G . Miliaras D . Kotronis K . Stamatopoulos P . Tarlatzis B . February 2016 . Immunohistochemical expression pattern of metastasis suppressors . European Journal of Obstetrics & Gynecology and Reproductive Biology . 199 . 110–115 . 10.1016/j.ejogrb.2016.02.004 . 26918694 .