K10 transport/localisation element (TLS) explained

K10 transport/localisation element (TLS)
Symbol:	K10_TLS
Rfam:	RF00207
Rna Type:	Cis-reg
Tax Domain:	Eukaryota

The K10 transport/localisation element (TLS) is a 44 nucleotide K10 TLS regulatory element from Drosophila melanogaster. K10 TLS is responsible for the transport and anterior localisation of K10 mRNA and acts to establish dorsoventral polarity in the oocyte.^{[1] [2]} It was discovered by Julia Serano.

Notes and References

1. Serano TL, Cohen RS . A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA . Development . 121 . 11 . 3809–3818 . November 1995 . 10.1242/dev.121.11.3809 . 8582290 .
2. Guillemin K, Williams T, Krasnow MA . A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila . Nature Cell Biology . 3 . 9 . 848–851 . September 2001 . 11533666 . 10.1038/ncb0901-848 . 15530627 .