K+-transporting ATPase explained

potassium-transporting ATPase
Ec Number:3.6.3.12
Go Code:0008556

In enzymology, a K+-transporting ATPase is an enzyme that catalyzes the chemical reaction

ATP + H2O + K+out ADP + phosphate + K+in

The 3 substrates of this enzyme are ATP, H2O, and K+, whereas its 3 products are ADP, phosphate, and K+.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (K+-importing). Other names in common use include K+-translocating Kdp-ATPase, and multi-subunit K+-transport ATPase. This enzyme participates in two-component system - general.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References