Justin Rhodes Explained
Justin S. Rhodes is an American neuroscientist and a professor in the Department of Psychology at the University of Illinois at Urbana-Champaign.[1] He is affiliated with the Neuroscience Program, Program of Ecology, Evolution, & Conservation Biology, the Carl R. Woese Institute for Genomic Biology, and the Neurotech group at Beckman Institute for Advanced Science and Technology. After receiving a Bachelor of Science in biology at Stanford University, Rhodes obtained a PhD in zoology in 2002 from University of Wisconsin–Madison, under the supervision of Theodore Garland, Jr. After completing a postdoctoral fellowship at Oregon Health & Science University, he held a position as an instructor at Lewis & Clark College for a year before accepting a full-time faculty position in 2005 in the biological division of the Department of Psychology at the University of Illinois. His lab investigates a broad array of topics in the field of neuroscience with particular emphasis in exercise-induced hippocampal neurogenesis, neural circuitry involved in addictive behaviors, and brain plasticity in clownfish.
Research
Rhodes research interests relate to neuronal plasticity. One interest includes understanding the role of voluntary exercise via wheel running in inducing the formation of new neurons in the dentate gyrus of the hippocampus.[2] A major goal of this research would be to understand the biological organization, from gene and protein expressions, that regulate neurogenesis in the hippocampus.
Rhodes was one of the developers of the Drinking in the Dark model in mice. In this model, a specific mouse strain is found to voluntarily drink to the levels of intoxication. Many drugs used to treat alcoholism in humans have been shown to lead to reduced ethanol consumption in mice used in this model.[3] [4]
Another interest includes understanding changes in neural circuitry due to drug addiction. Research from his lab has shown that adult and adolescent mice given equal amounts of cocaine display significant differences in locomotor stimulation.[5] His research has also shown that voluntary behaviors such as exercise could activate the same neurobiological pathways as alcohol and drug addiction.[6] Most recently, his lab is investigating the impact of exercise on drug associative learning.[7] As a career project, Rhodes tries to understand the evolution of behavior by selectively breeding for hyperactivity in mice. The overall goal is to identify how genes regulate multiple levels of biological organization.[8]
Currently, Rhodes has also established a marine biology laboratory to research brain plasticity in clownfish undergoing sex change as a result of removal of the largest female from the group.[9] [10]
Awards and honors
Notable publications
- 438–55 . 10.1093/icb/45.3.438 . Neurobiology of mice selected for high voluntary wheel-running activity . 2005 . Rhodes . J. S. . . 45 . 3 . 21676789 . Gammie . SC . Garland, Jr . T. free .
- 26–33 . 10.1016/j.coph.2004.12.001 . Gene expression induced by drugs of abuse . 2005 . Rhodes . Justin S . Crabbe . John C . . 5 . 15661622 . 1.
- 17233637 . 2007 . Rhodes . JS . Ford . MM . Yu . CH . Brown . LL . Finn . DA . Garland, Jr . T . Crabbe . JC . Mouse inbred strain differences in ethanol drinking to intoxication . 6 . 1 . 1–18 . 10.1111/j.1601-183X.2006.00210.x . Genes, Brain and Behavior.
- 1048–58 . 10.1016/j.neuroscience.2008.06.051 . Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice . 2008 . Clark . P.J. . Brzezinska . W.J. . Thomas . M.W. . Ryzhenko . N.A. . Toshkov . S.A. . Rhodes . J.S. . . 155 . 4 . 18664375. 15051523 .
- Book: Rhodes . J. S. . Kawecki . T. . 2009 . Behavior and Neurobiology . Garland . T. . Theodore Garland, Jr. . M. R. Rose . Experimental Evolution . University of California Press . 263–300.
- 1087–99 . 10.1016/j.neuroscience.2009.11.038 . Patterns of neural activity associated with differential acute locomotor stimulation to cocaine and methamphetamine in adolescent versus adult male C57BL/6J mice . 2010 . Zombeck . J.A. . Lewicki . A.D. . Patel . K. . Gupta . T. . Taruna Madan Gupta . Rhodes . J.S. . Neuroscience . 165 . 4 . 19932887 . 2814970.
- 289–313 . Male superiority in spatial navigation . 2012 . Clint . E.K. . Sober . E. . Garland . T. Jr. . Rhodes . J.S. . . 87 . 4 . 10.1086/668168. 23397795 . 1001894 .
Notes and References
- Web site: Justin Rhodes . Department of Psychology, University of Illinois at Urbana-Champaign . 2011-01-04.
- Web site: How Exercise Could Lead to a Better Brain . Article. New York Times. 2012 . 2012-04-20.
- 18782337 . 2008 . Gupta . T . Syed . YM . Revis . AA . Miller . SA . Martinez . M . Cohn . KA . Demeyer . MR . Patel . KY . Brzezinska . WJ . Rhodes . JS . Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice . 32 . 11 . 1992–1998 . 10.1111/j.1530-0277.2008.00787.x . .
- 17273875 . 2007 . Kamdar . NK . Miller . SA . Syed . YM . Bhayana . R . Gupta . T . Rhodes . JS . Acute effects of naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice . 192 . 2 . 207–17 . 10.1007/s00213-007-0711-5 . Psychopharmacology. 12497800 .
- Web site: Teen brain less sensitive to cocaine? . Futurity . 2010 . 2011-01-04 .
- Web site: Rhodes Probes Causal Mechanisms of Voluntary Behavior . Beckman Institute . 2007 . 2011-01-04 . dead . https://web.archive.org/web/20110717212007/http://www.beckman.illinois.edu/news/032807 . 2011-07-17 .
- Web site: How Exercise Can Prime the Brain for Addiction . New York Times. 2012 . 2012-04-12.
- Web site: Research . Beckman Institute . Rhodes . JS . 2011-03-21 . dead . https://web.archive.org/web/20110719211155/http://rhodeslab.beckman.illinois.edu/research/research.htm . 2011-07-19 .
- Web site: Explorer's Guide: Anemone Clownfish . Shedd Aquarium . 2011-01-04 . dead . https://web.archive.org/web/20110724104216/http://sea.sheddaquarium.org/sea/fact_sheets.asp?id=72 . 2011-07-24 .
- Web site: Nemo Meets Neuroscience . Beckman Institute . 2013-12-09.
- Web site: IBANGS Awards . . 2011-01-04.