Julie Ahringer Explained

Julie Ahringer
Birth Name:Julie Ann Ahringer
Nationality:American
Workplaces:Gurdon Institute
University of Cambridge
Laboratory of Molecular Biology
University of Wisconsin–Madison
Thesis Title:Post-transcriptional regulation of fem-3, a sex-determining gene of Caenorhabditis elegans
Thesis Url:http://search.proquest.com/docview/303972449
Thesis Year:1991
Doctoral Advisor:Judith Kimble
Academic Advisors:John Graham White
Known For:RNA interference[1]
Caenorhabditis elegans[2] [3] [4] [5] [6]

Julie Ann Ahringer is an American/British Professor of Genetics and Genomics, Director of the Gurdon Institute and a member of the Department of Genetics at the University of Cambridge.[7] [8] She leads a research lab investigating the control of gene expression.

Her laboratory carried out the first systematic inactivation of the majority of genes in an animal through constructing and screening a genome-wide RNA interference library for the nematode worm Caenorhabditis elegans.[9] Research in Ahringer's lab investigates the control of gene expression and genome architecture in development, using C. elegans as a model system.[10]

Education

Ahringer is from Miami, Florida[11] and was educated at Lafayette College in Easton, Pennsylvania, where she was awarded a Bachelor of Arts degree in Chemistry in 1984.[12] She completed her PhD at the University of Wisconsin–Madison while working with Judith Kimble.[13] [14] [15]

Research and career

After her Phd, she carried out postdoctoral research at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge with John Graham White.[16] Ahringer became a group leader in the department of genetics in Cambridge in 1996, before moving to the Gurdon Institute in 1998.[17] Her laboratory carried out the first systematic inactivation of the majority of genes in any animal by constructing and screening a genome-wide RNAi library for Caenorhabditis elegans (C. elegans). Ahringer's research group studies the regulation of chromatin structure and function in gene expression and genome organization using the nematode C. elegans as a model to understand development and disease. The Ahringer Lab research is funded by the Wellcome Trust.[7]

Honors and awards

Ahringer was elected to the EMBO Membership in 2003[18] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2007.[19] She delivered the Francis Crick lecture prize of the Royal Society in 2004.[20] In 2020 she was awarded the George W. Beadle Award of the Genetics Society of America for outstanding contributions to genetics.[21] She was elected a Fellow of the Royal Society in 2021.[22]

She serves as a member of the scientific advisory board of the Medical Research Council (MRC) along with many other eminent scientists.[23]

Personal life

Ahringer married Richard Durbin in 1996, with whom she has two children.

Notes and References

  1. Qu . W. . Ren . C. . Li . Y. . Shi . J. . Zhang . J. . Wang . X. . Hang . X. . Lu . Y. . Zhao . D. . Zhang . C. . Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: A guide for genome-wide screens . 10.1186/1471-2164-12-170 . BMC Genomics . 12 . 170 . 2011 . 21453524. 3087708 . free .
  2. N.. Moreno. Le Bot . A.. Kanapin . S. . Sohrmann . M. . Welchman . D. P. . Zipperlen . P. . Ahringer . J.. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature. 231–237. 6920. 421 . M.. Gotta . R.. Fraser. Kamath. 2003. 12529635 . A.. Dong. Durbin . R. . G.. Poulin . Y.. 10.1038/nature01278 . 2003Natur.421..231K. 15745225.
  3. Ahringer . J. . Julie Ahringer. Kamath . A. G. . Zipperlen . R. S. . Martinez-Campos . P. . Sohrmann . M. . Ahringer . M. . Functional genomic analysis of C. Elegans chromosome I by systematic RNA interference . Nature . 408 . 6810 . 325–330 . 2000 . 10.1038/35042517 . 11099033. 2000Natur.408..325F . 4373444 .
  4. Murphy . C. T. . McCarroll . S. A. . Bargmann . C. I. . Fraser . A. . Kamath . R. S. . Ahringer . J. . Li . H. . Kenyon . C. . 10.1038/nature01789 . Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans . Nature . 424 . 6946 . 277–283 . 2003 . 12845331. 2003Natur.424..277M . 4424249 .
  5. Ashrafi . K. . Chang . F. Y. . Watts . J. L. . Fraser . A. G. . Kamath . R. S. . Ahringer . J. . Ruvkun . G. . 10.1038/nature01279 . Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes . Nature . 421 . 6920 . 268–272 . 2003 . 12529643. 2003Natur.421..268A . 4321264 .
  6. Lee . S. S. . Lee . R. Y. N. . Fraser . A. G. . Kamath . R. S. . Ahringer . J. . Ruvkun . G. . 10.1038/ng1056 . A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity . . 33 . 1 . 40–48 . 2002 . 12447374. 17681940 .
  7. Web site: Home | Ahringer Lab. Florence Leroy based on Custom Repute template. Gurdon.cam.ac.uk. https://web.archive.org/web/20161017074039/http://www2.gurdon.cam.ac.uk/~ahringerlab/. 2016-10-17. dead. 2016-12-19.
  8. Pocock . R. . Ahringer . J. . Julie Ahringer. Mitsch . M. . Maxwell . S. . Woollard . A. . Alison Woollard. A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. Elegans . 10.1242/dev.01110 . Development . 131 . 10 . 2373–2385 . 2004 . 15102704 . free .
  9. Web site: Outstanding Women In Science Seminar series: Julie Ahringer. NCCR in Chemical Biology. en-US. 2019-04-06.
  10. Web site: Ahringer Lab — The Gurdon Institute. www.ahringer.group.gurdon.cam.ac.uk/. en. 2020-12-10.
  11. Web site: PROFESSOR GETS GRANT FOR CHEMICAL RESEARCH. Call. The Morning. themorningcall.com. 8 March 1984 . en-US. 2019-04-06.
  12. Julie Ahringer
  13. PhD . Julie Ann. Ahringer . Posttranscriptional regulation offem-3, a sex-determining gene of Caenorhabditis elegans . University of Wisconsin–Madison . 1991 . Julie Ahringer. .
  14. Ahringer . J. . Rosenquist . T. A. . Lawson . D. N. . Kimble . J. . The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally . The EMBO Journal . 11 . 6 . 2303–2310 . 1992 . 1376249 . 556697. 10.1002/j.1460-2075.1992.tb05289.x .
  15. Ahringer . J. . Kimble . J. . 10.1038/349346a0 . Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region . Nature . 349 . 6307 . 346–348 . 1991 . 1702880 . 1991Natur.349..346A . 4304843 .
  16. 10.1016/S0092-8674(03)00985-1 . Malone . C. J. . Misner . L. . Le Bot . N. . Tsai . M. C. . Campbell . J. M. . Ahringer . J. . White . J. G. . The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus . Cell . 115 . 7 . 825–836 . 2003 . 14697201. 2605372 . free .
  17. Web site: Science Advisory Board Julie Ahringer. LMS London Institute of Medical Sciences. en. 2019-04-06.
  18. Web site: Find People in the EMBL Communities. 2017. 2018-10-09.
  19. Web site: Professor Julie Ahringer The Academy of Medical Science. 2018-10-09.
  20. Web site: Genes, worms and the new genetics. Julie. Ahringer. 2004. Royal Society. London. royalsociety.org.
  21. Web site: Congratulations to the recipients of the 2020 GSA Awards!. 29 January 2020. Genetics Society of America. 5 February 2020.
  22. Web site: 2021-05-06. The Royal Society announces election of new Fellows 2021. 2021-05-21. University of Cambridge. en.
  23. Web site: Scientific Advisory Board . http://webarchive.nationalarchives.gov.uk/20120703102051/http://www.csc.mrc.ac.uk/Administration/ScientificAdvisoryBoard/JulieAhringer/ . dead . 2012-07-03 . Csc.mrc.ac.uk . 2016-12-19 .

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