Julian Parkhill Explained

Julian Parkhill
Birth Name:Julian Parkhill
Birth Date:1964 9, df=yes
Birth Place:Leigh-on-Sea
Education:Westcliff High School for Boys
Thesis Title:Regulation of transcription of the mercury resistance operon of Tn501
Thesis Url:http://pmt-eu.hosted.exlibrisgroup.com/primo_library/libweb/action/display.do?doc=44BU_LMS_DS000519318&vid=44BU_VU1
Thesis Year:1991
Known For:ARTEMIS[1] [2] [3]

Julian Parkhill (born 1964) [4] is Professor of Bacterial Evolution in the Department of Veterinary Medicine[5] at the University of Cambridge. He previously served as head of pathogen genomics at the Wellcome Sanger Institute.[6] [7]

Education

Parkhill was educated at Westcliff High School for Boys, the University of Birmingham and the University of Bristol where he was awarded a PhD in 1991[8] for research into the regulation of transcription of the mercury resistance operon.[9] [10] [11]

Career and research

Parkhill uses high throughput sequencing and phenotyping to study pathogen diversity and variation, how they affect virulence and transmission, and what they tell us about the evolution of pathogenicity and host–pathogen interaction.[12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] Research in the Parkill Laboratory has been funded the Wellcome Trust, the Biotechnology and Biological Sciences Research Council (BBSRC)[25] and the Medical Research Council (MRC).[26]

Awards and honours

Parkhill was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2009,[4] and a Fellow of the American Academy of Microbiology (FAAM) in 2012.

Parkhill was elected a Fellow of the Royal Society (FRS) in 2014,[27] his certificate of election reads:

Notes and References

  1. 10.1093/bioinformatics/16.10.944. 11120685. Artemis: Sequence visualization and annotation. Bioinformatics. 16. 10. 944–5. 2000. Rutherford. K.. Parkhill. J.. Crook. J.. Horsnell. T.. Rice. P.. Rajandream. M.-A.. Barrell. B.. free.
  2. 18845581. 2008. Carver. T. Artemis and ACT: Viewing, annotating and comparing sequences stored in a relational database. Bioinformatics. 24. 23. 2672–6. Berriman. M. Tivey. A. Patel. C. Böhme. U. Barrell. B. G.. Parkhill. J. Rajandream. M. A.. 10.1093/bioinformatics/btn529. 2606163.
  3. Carver . T.. Harris . S. R.. Berriman . M.. Parkhill . J.. McQuillan . J. A.. Artemis: An integrated platform for visualization and analysis of high-throughput sequence-based experimental data. 10.1093/bioinformatics/btr703. Bioinformatics. 28. 4. 464–469. 2011. 22199388. 3278759.
  4. Web site: Fellow | Academy of Medical Sciences . Acmedsci.ac.uk . 2016-11-18 . https://web.archive.org/web/20161118164019/https://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-julian-parkhill/ . 18 November 2016 . dead .
  5. Web site: Professor Julian Parkhill. www.vet.cam.ac.uk. 4 June 2021 . en. 2023-06-10.
  6. Web site: https://web.archive.org/web/20160315093803/http://www.sanger.ac.uk/people/directory/parkhill-julian. 2016-03-15. Professor Julian Parkhill, FRS, FMedSci, Senior Group Leader.
  7. 10.1038/nrmicro3112. 23979431. What has high-throughput sequencing ever done for us?. Nature Reviews Microbiology. 11. 10. 664–5. 2013. Parkhill . J.. 28613490.
  8. PhD . Julian. Parkhill . Regulation of transcription of the mercury resistance operon of Tn501 . University of Bristol . 1991 . 931563576. .
  9. 2169606. 1990. Parkhill. J. Site-specific insertion and deletion mutants in the mer promoter-operator region of Tn501; the nineteen base-pair spacer is essential for normal induction of the promoter by MerR. Nucleic Acids Research. 18. 17. 5157–62. Brown. N. L.. 332137 . 10.1093/nar/18.17.5157.
  10. 1717500. 1991. Brown. N. L.. Bacterial resistances to mercury and copper. Journal of Cellular Biochemistry. 46. 2. 106–14. Camakaris. J. Lee. B. T.. Williams. T. Morby. A. P.. Parkhill. J. Rouch. D. A.. 10.1002/jcb.240460204. 40277026.
  11. Holden . M. T. G. . Feil . E. . Lindsay . J. . Peacock . S. . Day . N. . Enright . M. . Foster . T. . Moore . C. . Hurst . L. . Laurence Hurst. Atkin . R. . Barron . A. . Bason . N. . Bentley . S. D. . Chillingworth . C. . Chillingworth . T. . Churcher . C. . Clark . L. . Corton . C. . Cronin . A. . Doggett . J. . Dowd . L. . Feltwell . T. . Hance . Z. . Harris . B. . Hauser . H. . Holroyd . S. . Jagels . K. . James . K. D. . Lennard . N. . Line . A. . Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance . 10.1073/pnas.0402521101 . Proceedings of the National Academy of Sciences . 101 . 26 . 9786–9791 . 2004 . 15213324 . 470752 . 2004PNAS..101.9786H . free .
  12. 20670392. 2010. Parkhill. J. Julian Parkhill. Genomic information infrastructure after the deluge. Genome Biology. 11. 7. 402. Birney. E. Ewan Birney. Kersey. P. 10.1186/gb-2010-11-7-402. 2926780. free.
  13. 10.1038/31159. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 393. 6685. 537–44. 1998. Cole . S. T.. Brosch . R.. Parkhill . J.. Garnier . T.. Churcher . C.. Harris . D.. Gordon . S. V.. Eiglmeier . K.. Gas . S.. Barry . C. E.. Tekaia . F.. Badcock . K.. Basham . D.. Brown . D.. Chillingworth . T.. Connor . R.. Davies . R.. Devlin . K.. Feltwell . T.. Gentles . S.. Hamlin . N.. Holroyd . S.. Hornsby . T.. Jagels . K.. Krogh . A.. McLean . J.. Moule . S.. Murphy . L.. Oliver . K.. Osborne . J.. 29 . 9634230. 1998Natur.393..537C. free.
  14. 10.1038/417141a. 12000953. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 417. 6885. 141–7. 2002. Bentley . S. D.. Chater . K. F.. Cerdeño-Tárraga . A. -M. . Challis . G. L.. Thomson . N. R.. James . K. D.. Harris . D. E.. Quail . M. A.. Kieser . H.. Harper . D.. Bateman . A.. Brown . S.. Chandra . G.. Chen . C. W.. Collins . M.. Cronin . A.. Fraser . A.. Goble . A.. Hidalgo . J.. Hornsby . T.. Howarth . S.. Huang . C. -H. . Kieser . T.. Larke . L.. Murphy . L.. Oliver . K.. O'Neil . S.. Rabbinowitsch . E.. Rajandream . M. -A. . Rutherford . K.. 2002Natur.417..141B. 4430218. 29. free.
  15. Qin . J. . Li . R. . Raes . J. . Arumugam . M. . Burgdorf . K. S. . Manichanh . C. . Nielsen . T. . Pons . N. . Levenez . F. . Yamada . 10.1038/nature08821 . T. . Mende . D. R. . Li . J. . Xu . J. . Li . S. . Li . D. . Cao . J. . Wang . B. . Liang . H. . Zheng . H. . Xie . Y. . Tap . J. . Lepage . P. . Bertalan . M. . Batto . J. M. . Hansen . T. . Le Paslier . D. . Linneberg . A. . Nielsen . H. B. R. . Pelletier . E. . Renault . P. . A human gut microbial gene catalogue established by metagenomic sequencing . Nature . 464 . 7285 . 59–65 . 2010 . 20203603 . 3779803. 2010Natur.464...59. .
  16. 10.1038/35001088. 10688204. 2000. Parkhill . J.. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature. 403. 6770. 665–8. Wren . B. W.. Mungall . K.. Ketley . J. M.. Churcher . C.. Basham . D.. Chillingworth . T.. Davies . R. M.. Feltwell . T.. Holroyd . S.. Jagels . K.. Karlyshev . A. V.. Moule . S.. Pallen . M. J.. Penn . C. W.. Quail . M. A.. Rajandream . M. A. . Rutherford . K. M.. Van Vliet . A. H. M.. Whitehead . S.. Barrell . B. G.. 2000Natur.403..665P. free.
  17. Cole . S. T. . Eiglmeier . K. . Parkhill . J. . James . K. D. . Thomson . N. R. . Wheeler . P. R. . Honoré . N. . Garnier . T. . Churcher . C. . Harris . 10.1038/35059006 . D. . Mungall . K. . Basham . D. . Brown . D. . Chillingworth . T. . Connor . R. . Davies . R. M. . Devlin . K. . Duthoy . S. . Feltwell . T. . Fraser . A. . Hamlin . N. . Holroyd . S. . Hornsby . T. . Jagels . K. . Lacroix . C. . MacLean . J. . Moule . S. . Murphy . L. . Oliver . K. . Quail . M. A. . Massive gene decay in the leprosy bacillus . Nature . 409 . 6823 . 1007–1011 . 2001 . 11234002 . 2001Natur.409.1007C . 4307207 .
  18. 10.1038/35097083. 11586360. Genome sequence of Yersinia pestis, the causative agent of plague. Nature. 413. 6855. 523–7. 2001. Parkhill . J.. Julian Parkhill. Wren . B. W.. Thomson . N. R.. Titball . R. W.. Holden . M. T. G.. Prentice . M. B.. Sebaihia . M.. James . K. D.. Churcher . C.. Mungall . K. L.. Baker . S.. Basham . D.. Bentley . S. D.. Brooks . K.. Cerdeño-Tárraga . A. M.. Chillingworth . T.. Cronin . A.. Davies . R. M.. Davis . P.. Dougan . G.. Feltwell . T.. Hamlin . N.. Holroyd . S.. Jagels . K.. Karlyshev . A. V.. Leather . S.. Moule . S.. Oyston . P. C. F.. Quail . M.. Rutherford . K.. 2001Natur.413..523P. 29. free.
  19. 10.1038/35101607. 11677608. 2001. Parkhill . J.. Julian Parkhill. Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature. 413. 6858. 848–52. Dougan . G.. Gordon Dougan. James . K. D.. Thomson . N. R.. Pickard . D.. Wain . J.. Churcher . C.. Mungall . K. L.. Bentley . S. D.. Holden . M. T. G.. Sebaihia . M.. Baker . S.. Basham . D.. Brooks . K.. Chillingworth . T.. Connerton . P.. Cronin . A.. Davis . P.. Davies . R. M.. Dowd . L.. White . N.. Farrar . J.. Feltwell . T.. Hamlin . N.. Haque . A.. Hien . T. T.. Holroyd . S.. Jagels . K.. Krogh . A.. Larsen . T. S.. 2001Natur.413..848P. 29. free.
  20. 10.1038/35006655. Complete DNA sequence of a serogroup a strain of Neisseria meningitidis Z2491. Nature. 404. 6777. 502–6. 2000. Parkhill . J. . Julian Parkhill. Achtman . M. . Mark Achtman. James . K. D.. Bentley . S. D.. Churcher . C.. Klee . S. R. . Morelli . G.. Basham . D.. Brown . D.. Chillingworth . T.. Davies . R. M. . Davis . P.. Devlin . K.. Feltwell . T.. Hamlin . N.. Holroyd . S.. Jagels . K.. Leather . S.. Moule . S.. Mungall . K.. Quail . M. A.. Rajandream . M. -A. . Rutherford . K. M.. Simmonds . M.. Skelton . J.. Whitehead . S.. Spratt . B. G.. Barrell . B. G. . 10761919. 2000Natur.404..502P. 4430718.
  21. 10.1186/gb-2011-12-10-230. 22027015. Bacterial epidemiology and biology - lessons from genome sequencing. Genome Biology. 12. 10. 230. 2011. Parkhill . J. . Wren . B. W. . 3333767. free.
  22. 10.1073/pnas.1130426100. The complete genome sequence of Mycobacterium bovis . Proceedings of the National Academy of Sciences. 100. 13. 7877–82. 2003. Garnier . T.. Eiglmeier . K.. Camus . J. -C. . Medina . N.. Mansoor . H.. Pryor . M.. Duthoy . S.. Grondin . S.. Lacroix . C.. Monsempe . C.. Simon . S.. Harris . B.. Atkin . R.. Doggett . J.. Mayes . R.. Keating . L.. Wheeler . P. R.. Parkhill . J.. Barrell . B. G.. Cole . S. T.. Gordon . S. V.. Hewinson . R. G. . 12788972 . 164681. 2003PNAS..100.7877G . free .
  23. 10.1038/ng1227. 12910271. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica . Nature Genetics. 35. 1. 32–40. 2003. Parkhill . J. . Julian Parkhill. Sebaihia . M. . Preston . A. . Murphy . L. D. . Thomson . N. . Harris . D. E. . Holden . M. T. G. . Churcher . C. M. . Bentley . S. D. . Mungall . K. L. . Cerdeño-Tárraga . A. M. . Temple . L. . James . K. . Harris . B. . Quail . M. A. . Achtman . M. . Mark Achtman. Atkin . R. . Baker . S. . Basham . D. . Bason . N. . Cherevach . I. . Chillingworth . T. . Collins . M. . Cronin . A. . Davis . P. . Doggett . J. . Feltwell . T. . Goble . A. . Hamlin . N. . Hauser . H. . 29. free .
  24. 10.1038/nbt1360. 18464787. The minimum information about a genome sequence (MIGS) specification. Nature Biotechnology. 26. 5. 541–7. 2008. Field . D. . Garrity . G. . Gray . T. . Morrison . N. . Selengut . J. . Sterk . P. . Tatusova . T. . Thomson . N. . Allen . M. J. . Angiuoli . S. V. . Ashburner . M. . Axelrod . N. . Baldauf . S. . Ballard . S. . Boore . J. . Cochrane . G. . Cole . J. . Dawyndt . P. . De Vos . P. . Depamphilis . C. . Edwards . R. . Faruque . N. . Feldman . R. . Gilbert . J. . Gilna . P. . Glöckner . F. O. . Goldstein . P. . Guralnick . R. . Haft . D. . Hancock . D. . 29 . 2409278.
  25. Web site: https://web.archive.org/web/20160304034459/http://www.bbsrc.ac.uk/research/grants-search/PersonDetails/?Personid=104217. 2016-03-04. Grants awarded to Julian Parkhill by the BBSRC. BBSRC. Anon. 2014.
  26. Web site: https://web.archive.org/web/20150421112455/http://gtr.rcuk.ac.uk/person/236D4E9F-1D21-4C1B-A859-7A8128054A0C. 2015-04-21. UK Government grants awarded to Julian Parhill. Anon. 2014. Research Councils UK. Swindon.
  27. Web site: https://web.archive.org/web/20151117101946/https://royalsociety.org/people/julian-parkhill-12046/ . 2015-11-17 . Anon . 2014 . Professor Julian Parkhill FMedSci FRS . . London . One or more of the preceding sentences incorporates text from the royalsociety.org website where:

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