Julia Mahamid Explained

Julia Mahamid
Thesis Title:Structural Investigation of Bone Mineralization Processes in the Zebrafish Fin and Embryonic Mouse Models[1]
Thesis Year:2010
Known For:cryo-electron tomography
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Julia Mahamid is a cell biologist, structural biologist, and electron microscopist at the European Molecular Biology Laboratory in Heidelberg, Germany, who utilizes biomolecular condensates and advanced cellular cryo-electron tomography to enhance the comprehension of the functional organization of the cytoplasm. She leads the Mahamid Group.[2]

Education

Mahamid completed her Biology studies at the Technion – Israel Institute of Technology, Israel between 2000 and 2003. After that, she pursued her Master's degree in Chemistry from 2003 to 2005, at the Weizmann Institute of Science, Israel, under the guidance of Lia Addadi in collaboration with Dan Caspi. Later, from 2006 to 2010, Mahamid completed her Ph.D. studies under the supervision of Lia Addadi and Steve Weiner.[1]

Career and research

For her postgraduate work, from 2011 to 2017, Mahamid worked as a postdoctoral researcher the guidance of Wolfgang Baumeister at the Max Planck Institute of Biochemistry in Martinsried, Germany.[3] [4] [5]

Since 2017, Mahamid has been a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany.[6] [7] [8] [9] [10] [11]

Mahamid's research is based on the development of new methods for cryo-electron tomography (cryo-ET), which is a technique for high-resolution 3D imaging of cellular machinery in its natural state. Mahamid played a key role in the development of the cryo-focused ion beam (cryo-FIB) technique that facilitated the creation of "electron-transparent windows" in cells, enabling the observation of cellular structures and macromolecular complexes in their natural environment.[12]

Mahamid is a well-known cell biologist, structural biologist, and electron microscopist. Hence, she is frequently invited to speak at seminars,[13] [14] [15] workshops,[16] [17] [18] and conferences[19] [20] in the field.

Mahamid is on the editorial board of the Journal of Structural Biology.[21]

Awards and honours

Notes and References

  1. https://www.academia-net.org/profile/julia-mahamid/77167
  2. Web site: Mahamid Group – In-cell structural analysis of phase separation and molecular crowding .
  3. https://en.bio-protocol.org/en/bpdetail?id=1575
  4. A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms . 10.1016/j.jsb.2015.07.012 . 2015 . Mahamid . Julia . Schampers . Ruud . Persoon . Hans . Hyman . Anthony A. . Baumeister . Wolfgang . Plitzko . Jürgen M. . Journal of Structural Biology . 192 . 2 . 262–269 . 26216184 .
  5. Visualizing the molecular sociology at the HeLa cell nuclear periphery . 10.1126/science.aad8857 . 2016 . Mahamid . Julia . Pfeffer . Stefan . Schaffer . Miroslava . Villa . Elizabeth . Danev . Radostin . Kuhn Cuellar . Luis . Förster . Friedrich . Hyman . Anthony A. . Plitzko . Jürgen M. . Baumeister . Wolfgang . Science . 351 . 6276 . 969–972 . 26917770 . 2016Sci...351..969M . 206645446 .
  6. 10.1038/s41592-019-0630-5 . Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies . 2020 . Toro-Nahuelpan . Mauricio . Zagoriy . Ievgeniia . Senger . Fabrice . Blanchoin . Laurent . Théry . Manuel . Mahamid . Julia . Nature Methods . 17 . 1 . 50–54 . 31740821 . 6949126 .
  7. 10.7554/eLife.68946 . free . Locating macromolecular assemblies in cells by 2D template matching with cisTEM . 2021 . Lucas . Bronwyn A. . Himes . Benjamin A. . Xue . Liang . Grant . Timothy . Mahamid . Julia . Grigorieff . Nikolaus . eLife . 10 . e68946 . 34114559 . 8219381 .
  8. 10.7554/eLife.70506 . free . A modular platform for automated cryo-FIB workflows . 2021 . Goetz . Sara K. . Fung . Herman KH . Klumpe . Sven . Zagoriy . Ievgeniia . Hampoelz . Bernhard . Zhang . Xiaojie . Erdmann . Philipp S. . Baumbach . Janina . Müller . Christoph W. . Beck . Martin . Plitzko . Jürgen M. . Mahamid . Julia . eLife . 10 . 34951584 . 8769651 .
  9. Protein condensates as aging Maxwell fluids . 10.1126/science.aaw4951 . 2020 . Jawerth . Louise . Fischer-Friedrich . Elisabeth . Saha . Suropriya . Wang . Jie . Franzmann . Titus . Zhang . Xiaojie . Sachweh . Jenny . Ruer . Martine . Ijavi . Mahdiye . Saha . Shambaditya . Mahamid . Julia . Hyman . Anthony A. . Jülicher . Frank . Science . 370 . 6522 . 1317–1323 . 33303613 . 2020Sci...370.1317J . 226035825 .
  10. In-cell architecture of the nuclear pore and snapshots of its turnover . 10.1038/s41586-020-2670-5 . 2020 . Allegretti . Matteo . Zimmerli . Christian E. . Rantos . Vasileios . Wilfling . Florian . Ronchi . Paolo . Fung . Herman K. H. . Lee . Chia-Wei . Hagen . Wim . Turoňová . Beata . Karius . Kai . Börmel . Mandy . Zhang . Xiaojie . Müller . Christoph W. . Schwab . Yannick . Mahamid . Julia . Pfander . Boris . Kosinski . Jan . Beck . Martin . Nature . 586 . 7831 . 796–800 . 32879490 . 2020Natur.586..796A . 21.11116/0000-0006-F3B5-B . 221462632 . free .
  11. 10.1126/science.abb3758 . In-cell architecture of an actively transcribing-translating expressome . 2020 . o'Reilly . Francis J. . Xue . Liang . Graziadei . Andrea . Sinn . Ludwig . Lenz . Swantje . Tegunov . Dimitry . Blötz . Cedric . Singh . Neil . Hagen . Wim J. H. . Cramer . Patrick . Stülke . Jörg . Mahamid . Julia . Rappsilber . Juri . Science . 369 . 6503 . 554–557 . 32732422 . 7115962 . 2020Sci...369..554O .
  12. Web site: Julia Mahamid receives EMBO Gold Medal 2023 – Press releases – EMBO . 6 June 2023 .
  13. Web site: CSSB Seminar Series - JULIA MAHAMID .
  14. Web site: Female Rising Stars, Dr. Julia Mahamid, Group Leader, Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany .
  15. Web site: CryoEM Seminar @ITQB NOVA - Julia Mahamid .
  16. Web site: iNEXT-Discovery hands-on workshop: cryo-FIB lamella preparation & cryo electron tomography - Sciencesconf.org. inextfibet.sciencesconf.org. 27 November 2023.
  17. Web site: In situ structural biology: From cryo-EM to multi-scale modelling – Course and Conference Office .
  18. Web site: Cryo-EM in academia and industry – Course and Conference Office .
  19. Web site: 2023 Three Dimensional Electron Microscopy Conference GRC .
  20. Web site: Seeing is Believing: Imaging the Molecular Processes of Life – Course and Conference Office .
  21. Web site: Julia Mahamid, PhD - Editorial Board - Journal of Structural Biology - Journal - Elsevier .
  22. https://erc.europa.eu/sites/default/files/document/file/erc_2017_stg_results_ls.pdf
  23. Web site: In situ Structural Analysis of Molecular Crowding and Phase Separation | 3DCellPhase- Project | Fact Sheet | H2020 .
  24. Julia Mahamid . 10.1038/s41592-021-01063-0 . 2021 . Marx . Vivien . Nature Methods . 18 . 2 . 117 . 33542512 . 231820823 .
  25. Web site: Hybrid Technologies for Structural Cell Biology at Near-Atomic Resolution .
  26. Web site: Illuminating protein complexes in cells . 18 June 2021 .
  27. Web site: EMBO Gold Medal 2023 awarded to ERC grantee .

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