Judy Hirst Explained

Judy Hirst
Workplaces:University of Cambridge
Scripps Research Institute
Alma Mater:University of Oxford
Thesis Title:Electron transport in redox enzymes
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364043
Thesis Year:1997
Doctoral Advisor:Fraser Armstrong[1]
Awards:Fellow of the Academy of Medical Sciences (2019)
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Judy Hirst is a British scientist specialising in mitochondrial biology. She is Director[2] of the MRC Mitochondrial Biology Unit at the University of Cambridge.

Early life and education

Hirst grew up in Lepton, a village near Huddersfield, West Yorkshire, and attended King James's School and Greenhead College, Huddersfield.[3] She studied for an M.A. in chemistry at St John's College, Oxford, and then was awarded a Doctor of Philosophy degree at Lincoln College, Oxford, in 1997, for research supervised by Fraser Armstrong on electron transport in redox enzymes.[4]

Career and research

Following her D.Phil., Hirst held a fellowship at the Scripps Research Institute in California, before moving to Cambridge.

Hirst is a professorial fellow and Director of Studies in Natural Sciences Chemistry at Corpus Christi College, Cambridge,[5] and since 2020 has been director of the MRC Mitochondrial Biology Unit having previously been its assistant director (2011-2014) and deputy director (2014-2020). Her main research interest is mitochondrial complex I.

Hirst has been published in 2018 on Open questions: respiratory chain supercomplexes – why are they there and what do they do?[6] and working with Justin Fedor, published research on mitochondrial supercomplexes in Cell Metabolism.[7] Recent research in her team includes a study, published in May 2020 by the American Chemical Society Synthetic Biology on 'Adenosine triphosphate (ATP), the cellular energy currency, is essential for life. The ability to provide a constant supply of ATP is therefore crucial for the construction of artificial cells in synthetic biology' which has developed a 'minimal system for cellular respiration and energy regeneration.[8]

Awards and honours

Early in her career, Hirst was awarded EMBO Young Investigator Award (2001) and Young Investigator Award from the Royal Society of Chemistry Inorganic Biochemistry Discussion Group (2006).[9]

Hirst was elected a Fellow of the Royal Society (FRS) in 2018.[10] She was awarded an Interdisciplinary Prize of the Royal Society of Chemistry in the same year.[11] In 2019, Hirst was elected Fellow of the Academy of Medical Sciences[12] with the citation:

Hirst was awarded Keilin Memorial Lecture and Medal in 2020 for research which:

Notes and References

  1. DPhil. University of Oxford. Electron transport in redox enzymes. Judy. Hirst. 1997. . bodleian.ox.ac.uk. 557413704.
  2. Web site: Judy Hirst FRS MRC Mitochondrial Biology Unit. 2020-08-16. www.mrc-mbu.cam.ac.uk. en. 8 May 2019. https://web.archive.org/web/20190508082720/http://www.mrc-mbu.cam.ac.uk/people/judy-hirst. dead.
  3. Web site: Dr Judy Hirst MA, DPhil, FRS. 2020-08-16. www.greenhead.ac.uk. en.
  4. DPhil. University of Oxford. Electron transport in redox enzymes. Judy. Hirst. 1997. . bodleian.ox.ac.uk. 557413704.
  5. Web site: Dr Judy Hirst MA DPhil (Oxford) FRS FMedSci. Corpus Christi College. 3 July 2023.
  6. Hirst. Judy. 2018. Open questions: respiratory chain supercomplexes-why are they there and what do they do?. BMC Biol. 16. 1. 111. 10.1186/s12915-018-0577-5. 30382836. 6211484. 1741-7007. free.
  7. Fedor. Justin. Hirst. Judy. 2018. Mitochondrial Supercomplexes Do Not Enhance Catalysis by Quinone Channeling.. Cell Metab. 28. 3. 525–531.e4. 10.1016/j.cmet.2018.05.024. 29937372. 6125145. 1932-7420. free.
  8. Biner. Olivier. Fedor. Justin G.. Yin. Zhan. Hirst. Judy. 2020-06-19. Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration. ACS Synthetic Biology. 9. 6. 1450–1459. 10.1021/acssynbio.0c00110. 7611821 . 32383867. free.
  9. Web site: RSC Interdisciplinary Prize 2018 Winner. 2020-08-16. www.rsc.org.
  10. Web site: Judy Hirst. royalsociety.org. 10 May 2018.
  11. Web site: 2018 Interdisciplinary Prize Winner: Dr Judy Hirst. Royal Society of Chemistry. 10 May 2018.
  12. Web site: New Fellows: 50 top biomedical and health scientists join the Academy The Academy of Medical Sciences. 2020-08-16. acmedsci.ac.uk.