| Juana Rosa Aguirre | |
| Office: | First Lady of Chile |
| Term Label: | In role |
| Term Start: | December 25, 1938 |
| Term End: | November 25, 1941 |
| President: | Pedro Aguirre Cerda |
| Predecessor: | Rosa Ester Rodríguez Velasco |
| Successor: | Marta Ide Pereira |
| Birth Name: | Juana Rosa Aguirre Luco |
| Birth Date: | 20 November 1877 |
| Birth Place: | Santiago, Chile |
| Nationality: | Chilean |
| Parents: | José Joaquín Aguirre Mercedes Luco Gutiérrez |
Juana Rosa Aguirre Luco (November 20, 1877 – December 8, 1962) was First Lady of Chile (between December 25, 1938- November 25, 1941) and the wife of President Pedro Aguirre Cerda, who was also her cousin.
She was the daughter of the popular doctor José Joaquín Aguirre Campos and his second wife Mercedes Luco Gutiérrez. She and Pedro Aguirre Cerda were married in 1916, but they never had children. She became the First Lady of Chile in 1938 when her husband assumed the presidency.[1]
She was greatly committed to education, was popular with the public, and was a supporter of women's participation in politics in Chile.[2]
After the death of her husband from tuberculosis in 1941, she established in his memory the Pedro Aguirre Cerda Children's Home Foundation to care for abandoned children.[3]