| Honorific-Prefix: | Don |
| Juan de Lezica y Torrezuri | |
| Order: | Mayor of |
| Office: | Buenos Aires |
| Term Start: | 1766 |
| Term End: | 1767 |
| Predecessor: | Eugenio Lerdo de Tejada |
| Successor: | Vicente de Azcuénaga |
| Birth Date: | July 26, 1709 |
| Birth Place: | Biscay, Spain |
| Death Date: | April 11, 1784 |
| Death Place: | Buenos Aires, Argentina |
| Restingplace: | Santo Domingo convent |
| Nationality: | Spanish |
| Occupation: | Politician |
| Profession: | architect engineer |
| Signature: | Juan de Lezica, firma 2.jpg |
| Branch: | Spanish Army |
| Commands: | "La Atrevida" |
Juan de Lezica y Torrezuri (1709–1784) was a Spanish nobleman, politician and merchant, who served as alcalde and regidor of Buenos Aires.
He was born in Cortézubi, Vizcaya, Spain, the son of Juan de Lezica y Gaçeaga and María de Torrezuri, belonging to a noble family of Basque roots. He was married to Elena de Alquiza y Peñaranda, born in La Paz daughter of Felipe de Alquiza and Juana María de Peñaranda.
Among other duties of public official, Juan de Lezica y Torrezuri was the commander of "La Atrevida", a militia of the Cuerpo de Blandengues de la Frontera de Buenos Aires, in charge of punitive expeditions against infidel Indians. He also served as mayor of 1st vote of Buenos Aires and of La Paz. In 1755, he founded the town of Luján.